{"doi":"10.1126/science.aba4904","title":"Structure of a human 48 <i>S</i> translational initiation complex","abstract":"Finding the start Eukaryotic translation involves many players in a dynamic and well-orchestrated process. A 43 S preinitiation complex (PIC) comprises the 40 S ribosomal subunit; initiation factors, including the eIF3 complex, which is known to play a key role; and the transfer RNA used for translation initiation. The PIC is recruited to the cap-binding complex eIF4F at the 5′ end of messenger RNA (mRNA) to form a 48 S complex that scans along the mRNA for a start codon. Brito Querido et al. determined the structure of a reconstituted human 48 S complex using cryo–electron microscopy. They found that eIF4F binds to eIF3 near the exit site of the ribosome. This positioning suggests that downstream mRNA is likely pulled through the 40 S subunit to find the start codon. Science , this issue p. 1220","journal":"Science","year":2020,"id":49166,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":286,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9546,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":236134,"name":"Masaaki Sokabe","orcid":"0000-0002-1824-4818","position":1,"is_corresponding":false},{"id":236135,"name":"S.H.W. Kraatz","orcid":"0000-0003-2265-9052","position":2,"is_corresponding":false},{"id":236136,"name":"Yuliya Gordiyenko","orcid":"0000-0002-4356-2228","position":3,"is_corresponding":false},{"id":236137,"name":"Mark Skehel","orcid":"0000-0002-2432-0901","position":4,"is_corresponding":false},{"id":236138,"name":"Christopher S. Fraser","orcid":"0000-0001-9626-7743","position":5,"is_corresponding":false},{"id":236139,"name":"V. Ramakrishnan","orcid":"0000-0002-4699-2194","position":6,"is_corresponding":false},{"id":236133,"name":"Jailson Brito Querido","orcid":"0000-0002-1438-1268","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-18T20:36:25.163232Z","pmid":"32883864","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}