{"doi":"10.1126/science.aay6912","title":"The Ccr4-Not complex monitors the translating ribosome for codon optimality","abstract":"Coupling translation and mRNA decay Gene expression requires messenger RNAs (mRNAs)—DNA-derived blueprints of genes—to be translated by protein-producing ribosomes. The levels of mRNAs are tightly regulated, in part by controlling their half-lives. In eukaryotic cells, mRNA half-life is largely linked to translational efficiency, but the mechanism underlying this link has remained elusive. Buschauer et al. used cryo–electron microscopy and RNA sequencing to show how a key regulator of mRNA degradation, the Ccr4-Not complex, monitors the ribosome during mRNA translation. They found that the Not5 subunit directly binds to a ribosomal site exposed specifically during inefficient decoding, thereby triggering mRNA degradation. Analysis of mutants revealed the importance of this sensing mechanism for mRNA homeostasis. Science , this issue p. eaay6912","journal":"Science","year":2020,"id":49028,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":305,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235111,"name":"Yoshitaka Matsuo","orcid":"0000-0001-9895-0028","position":1,"is_corresponding":false},{"id":235112,"name":"Takato Sugiyama","orcid":"0000-0001-8364-7050","position":2,"is_corresponding":false},{"id":238599,"name":"Ying-Hsin Chen","orcid":null,"position":3,"is_corresponding":false},{"id":235113,"name":"Najwa Alhusaini","orcid":"0000-0001-6489-1285","position":4,"is_corresponding":false},{"id":235114,"name":"Thomas J. Sweet","orcid":"0000-0003-1476-9059","position":5,"is_corresponding":false},{"id":235115,"name":"Ken Ikeuchi","orcid":"0000-0002-9578-7920","position":6,"is_corresponding":false},{"id":235116,"name":"Jingdong Cheng","orcid":"0000-0003-4442-377X","position":7,"is_corresponding":false},{"id":235117,"name":"Yasuko Matsuki","orcid":"0000-0002-4790-8054","position":8,"is_corresponding":false},{"id":235118,"name":"Risa Nobuta","orcid":"0000-0001-7826-9569","position":9,"is_corresponding":false},{"id":238600,"name":"Andrea Gilmozzi","orcid":null,"position":10,"is_corresponding":false},{"id":235119,"name":"Otto Berninghausen","orcid":"0000-0002-9255-0522","position":11,"is_corresponding":false},{"id":235120,"name":"Petr Těšina","orcid":"0000-0002-5227-1799","position":12,"is_corresponding":false},{"id":235121,"name":"Thomas Becker","orcid":"0000-0001-8458-2738","position":13,"is_corresponding":false},{"id":235122,"name":"Jeff Coller","orcid":"0000-0001-5662-8110","position":14,"is_corresponding":false},{"id":235123,"name":"Toshifumi Inada","orcid":"0000-0002-2695-588X","position":15,"is_corresponding":false},{"id":235124,"name":"Roland Beckmann","orcid":"0000-0003-4291-3898","position":16,"is_corresponding":false},{"id":235110,"name":"Robert Buschauer","orcid":"0000-0002-5794-4841","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-18T20:36:25.163232Z","pmid":"32299921","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}