{"doi":"10.1126/science.aay1813","title":"Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression","abstract":"Deconstructing a perilous loop Cancer cells that give rise to solid tumors reside in a specialized microenvironment containing growth factors that support tumor growth and progression. The mechanisms by which tumor cells within this so-called “niche” attract and sustain these growth factors are poorly understood. Studying a mouse model of squamous cell carcinoma, Taniguchi et al. identified a signaling loop initiated by certain tumor cells within the niche that become more invasive on exposure to transforming growth factor β (TGF-β). They show that the tumor cells release the cytokine interleukin-33, which induces the differentiation of nearby myeloid cells into macrophages. These macrophages in turn release TGF-β, which feeds back to the tumor cells, promoting their malignant progression. Science this issue p. eaay1813","journal":"Science","year":2020,"id":49202,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":282,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9396,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":236425,"name":"Ajit Elhance","orcid":"0000-0003-1900-4637","position":1,"is_corresponding":false},{"id":236426,"name":"Avery Van Duzer","orcid":"0000-0002-9442-6955","position":2,"is_corresponding":false},{"id":236427,"name":"Sushil Kumar","orcid":"0000-0002-9882-0722","position":3,"is_corresponding":false},{"id":236428,"name":"Justin J. Leitenberger","orcid":"0000-0001-6836-671X","position":4,"is_corresponding":false},{"id":236429,"name":"Naoki Oshimori","orcid":"0000-0002-5247-510X","position":5,"is_corresponding":false},{"id":236424,"name":"S. Taniguchi","orcid":"0000-0002-7461-8300","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-18T20:36:25.163232Z","pmid":"32675345","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}