{"doi":"10.1126/science.aay0524","title":"VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance","abstract":"Negative checkpoint regulators (NCRs) temper the T cell immune response to self-antigens and limit the development of autoimmunity. Unlike all other NCRs that are expressed on activated T lymphocytes, V-type immunoglobulin domain-containing suppressor of T cell activation (VISTA) is expressed on naïve T cells. We report an unexpected heterogeneity within the naïve T cell compartment in mice, where loss of VISTA disrupted the major quiescent naïve T cell subset and enhanced self-reactivity. Agonistic VISTA engagement increased T cell tolerance by promoting antigen-induced peripheral T cell deletion. Although a critical player in naïve T cell homeostasis, the ability of VISTA to restrain naïve T cell responses was lost under inflammatory conditions. VISTA is therefore a distinctive NCR of naïve T cells that is critical for steady-state maintenance of quiescence and peripheral tolerance.","journal":"Science","year":2020,"id":49134,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":290,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235903,"name":"Yanding Zhao","orcid":"0000-0002-6882-4888","position":1,"is_corresponding":false},{"id":235904,"name":"Elizabeth C. Nowak","orcid":"0000-0001-8791-6166","position":2,"is_corresponding":false},{"id":235905,"name":"Jiannan Li","orcid":"0000-0001-9744-7666","position":3,"is_corresponding":false},{"id":235906,"name":"Evelien Schaafsma","orcid":"0000-0002-3821-3568","position":4,"is_corresponding":false},{"id":235907,"name":"Isabelle Le Mercier","orcid":"0000-0002-2422-5170","position":5,"is_corresponding":false},{"id":238782,"name":"Sabrina Ceeraz","orcid":null,"position":6,"is_corresponding":false},{"id":235908,"name":"J. Louise Lines","orcid":"0000-0002-3766-8376","position":7,"is_corresponding":false},{"id":235909,"name":"Changwei Peng","orcid":"0000-0002-0710-9573","position":8,"is_corresponding":false},{"id":235910,"name":"Catherine Carrière","orcid":"0000-0002-3119-1247","position":9,"is_corresponding":false},{"id":55232,"name":"Xin Huang","orcid":"0000-0002-4252-6110","position":10,"is_corresponding":false},{"id":238783,"name":"Maria Day","orcid":null,"position":11,"is_corresponding":false},{"id":235911,"name":"Brent H. Koehn","orcid":"0000-0002-3669-2702","position":12,"is_corresponding":false},{"id":235912,"name":"Sam W. Lee","orcid":"0000-0002-4114-7338","position":13,"is_corresponding":false},{"id":235913,"name":"Milagros Silva Morales","orcid":"0000-0002-0794-2362","position":14,"is_corresponding":false},{"id":235914,"name":"Kristin A. Hogquist","orcid":"0000-0001-9963-5687","position":15,"is_corresponding":false},{"id":235915,"name":"Stephen C. Jameson","orcid":"0000-0001-9137-1146","position":16,"is_corresponding":false},{"id":235916,"name":"Daniel L. Mueller","orcid":"0000-0003-1621-0419","position":17,"is_corresponding":false},{"id":238784,"name":"Jay L. Rothstein","orcid":null,"position":18,"is_corresponding":false},{"id":52067,"name":"Bruce R. Blazar","orcid":"0000-0002-9608-9841","position":19,"is_corresponding":false},{"id":363,"name":"Chao Cheng","orcid":"0000-0002-5002-3417","position":20,"is_corresponding":false},{"id":235917,"name":"Randolph J. Noelle","orcid":"0000-0002-2222-2136","position":21,"is_corresponding":false},{"id":235902,"name":"Mohamed ElTanbouly","orcid":"0000-0001-7985-3839","position":0,"is_corresponding":true}],"reference_count":95,"raw_metadata":null,"created_at":"2026-07-18T20:36:25.163232Z","pmid":"31949051","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}