{"doi":"10.1126/science.aax2517","title":"Structure and selectivity engineering of the M <sub>1</sub> muscarinic receptor toxin complex","abstract":"Engineering a toxin Developing drugs that target a specific subtype in a G protein–coupled receptor (GPCR) family is a major challenge. Maeda et al. examined the basis of specificity of a snake venom toxin binding to muscarinic acetylcholine receptors (MAChRs), which mediate many functions of the central and parasympathetic nervous systems. They determined a structure that shows why the mamba venom toxin MT7 is specific for one receptor, M 1 AChR, and also explains how it inhibits downstream signaling. Based on this structure, they engineered MT7 to be selective for another receptor, M 2 AChR, instead of M 1 ChR. The toxin may present a promising scaffold for developing specific GPCR modulators. Science , this issue p. 161","journal":"Science","year":2020,"id":65348,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":59,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9517,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":345528,"name":"Jun Xu","orcid":"0000-0002-1600-583X","position":1,"is_corresponding":false},{"id":345529,"name":"Francois Marie Ngako Kadji","orcid":"0000-0002-9187-4584","position":2,"is_corresponding":false},{"id":345530,"name":"Mary J. Clark","orcid":"0000-0003-1176-5626","position":3,"is_corresponding":false},{"id":345531,"name":"Jiawei Zhao","orcid":"0000-0002-0582-2105","position":4,"is_corresponding":false},{"id":260358,"name":"Naotaka Tsutsumi","orcid":"0000-0002-3617-7145","position":5,"is_corresponding":false},{"id":108032,"name":"Junken Aoki","orcid":"0000-0001-9435-1896","position":6,"is_corresponding":false},{"id":345532,"name":"Roger K. Sunahara","orcid":"0000-0003-1702-8619","position":7,"is_corresponding":false},{"id":255551,"name":"Asuka Inoue","orcid":"0000-0003-0805-4049","position":8,"is_corresponding":false},{"id":218189,"name":"K. Christopher García","orcid":"0000-0001-9273-0278","position":9,"is_corresponding":false},{"id":251465,"name":"Brian K. Kobilka","orcid":"0000-0001-5958-3990","position":10,"is_corresponding":false},{"id":345527,"name":"Shoji Maeda","orcid":"0000-0002-7762-9793","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-18T21:13:23.327603Z","pmid":"32646996","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}