{"doi":"10.1126/science.aax0249","title":"Single-cell transcriptional diversity is a hallmark of developmental potential","abstract":"<jats:title>More diversity at the top</jats:title>\n                  <jats:p>\n                    A detailed knowledge of cell differentiation hierarchies is important for understanding diverse biological processes such as organ development, tissue regeneration, and cancer. Single-cell RNA sequencing can help elucidate these hierarchies, but it requires reliable computational methods for predicting cell lineage trajectories. Gulati\n                    <jats:italic>et al.</jats:italic>\n                    developed CytoTRACE, a computational framework based on the simple observation that transcriptional diversity—the number of genes expressed in a cell—decreases during differentiation. CytoTRACE outperformed other methods in several test cases and was successfully applied to study cellular hierarchies in healthy and tumor tissue.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Science</jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6476\" page=\"405\" related-article-type=\"in-this-issue\" vol=\"367\" xlink:href=\"10.1126/science.aax0249\">405</jats:related-article>\n                  </jats:p>","journal":"Science","year":2020,"id":13500,"datarank":10.290592106085185,"base_score":7.331714969726466,"endowment":7.331714969726466,"self_citation_contribution":1.0997572454589701,"citation_network_contribution":9.190834860626214,"self_endowment_contribution":1.0997572454589701,"citer_contribution":9.190834860626214,"corpus_percentile":98.6,"corpus_rank":null,"citation_count":1527,"citer_count":191,"citers_with_citation_signal":191,"citers_with_endowment":191,"datacite_reuse_total":25,"is_dataset":false,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"authors":[{"id":74131,"name":"Shaheen S. Sikandar","orcid":"0000-0003-1867-6378","position":1,"is_corresponding":false},{"id":110551,"name":"Daniel J. Wesche","orcid":"0000-0003-0513-1571","position":2,"is_corresponding":false},{"id":110552,"name":"Anoop Manjunath","orcid":"0000-0002-9821-5733","position":3,"is_corresponding":false},{"id":110553,"name":"Anjan Bharadwaj","orcid":"0000-0002-1095-8525","position":4,"is_corresponding":false},{"id":110554,"name":"Mark J. Berger","orcid":null,"position":5,"is_corresponding":false},{"id":110555,"name":"Francisco Ilagan","orcid":"0000-0002-5430-673X","position":6,"is_corresponding":false},{"id":74032,"name":"Angera H. Kuo","orcid":"0000-0001-6955-9951","position":7,"is_corresponding":false},{"id":110556,"name":"Robert W. Hsieh","orcid":null,"position":8,"is_corresponding":false},{"id":110557,"name":"Shang Cai","orcid":"0000-0003-0630-7719","position":9,"is_corresponding":false},{"id":110558,"name":"Maider Zabala","orcid":null,"position":10,"is_corresponding":false},{"id":110559,"name":"Ferenc A. Scheeren","orcid":"0000-0002-8304-9023","position":11,"is_corresponding":false},{"id":110560,"name":"Neethan A. Lobo","orcid":"0000-0002-2428-8358","position":12,"is_corresponding":false},{"id":110561,"name":"Dalong Qian","orcid":"0000-0002-6261-5188","position":13,"is_corresponding":false},{"id":110562,"name":"Feiqiao B. Yu","orcid":"0000-0003-3416-3046","position":14,"is_corresponding":false},{"id":110563,"name":"Frederick M. Dirbas","orcid":"0000-0003-3576-6404","position":15,"is_corresponding":false},{"id":55808,"name":"Michael F. Clarke","orcid":"0000-0001-6889-4926","position":16,"is_corresponding":false},{"id":17223,"name":"Aaron M. 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Gulati","orcid":"0000-0003-2798-6220","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":7.331714969726466,"endowment":7.331714969726466,"datacite_reuse_total":25,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31974247","pmcid":"PMC7694873","openalex_id":"https://openalex.org/W3002770500","authors":[],"funders":[{"funder_name":"National Science Foundation","grant_id":"DGE-1656518","title":null},{"funder_name":"U.S. Department of Defense","grant_id":"W81XWH-11-1-0287","title":null},{"funder_name":"U.S. Department of Defense","grant_id":"W81XWH-13-1-0281","title":null},{"funder_name":"U.S. Department of Defense","grant_id":"W81XWH-12-1-0020","title":null},{"funder_name":"National Cancer Institute","grant_id":"R00CA187192-03","title":null},{"funder_name":"National Cancer Institute","grant_id":"5R01CA100225-09","title":"Self-renewal of Normal and Leukemic Stem Cells"},{"funder_name":"National Cancer Institute","grant_id":"CA09302","title":null},{"funder_name":"Stanford Medical Science Training Program","grant_id":"5T32GM007365-38","title":null},{"funder_name":"NCI NIH HHS","grant_id":"T32 CA009302","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R00 CA187192","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA100225","title":null},{"funder_name":"National Institutes of Health","grant_id":"5T32CA009302-17","title":"CANCER ETIOLOGY PREVENTION DETECTION AND DIAGNOSIS"},{"funder_name":"National Institutes of Health","grant_id":"5R00CA187192-04","title":"Ultrasensitive Quantitation of Circulating Tumor DNA"},{"funder_name":"Stinehart-Reed foundation","grant_id":"","title":null},{"funder_name":"Stanford Bio-X Interdisciplinary Initiatives Seed Grants Program","grant_id":"","title":null},{"funder_name":"Stanford Bio-X Bowes Graduate Student Fellowship","grant_id":"","title":null},{"funder_name":"Virginia and D.K. 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