{"doi":"10.1126/science.aax0194","title":"mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence","abstract":"T cells maintain a quiescent state prior to activation. As inappropriate T cell activation can cause disease, T cell quiescence must be preserved. Despite its importance, the mechanisms underlying the \"quiescent state\" remain elusive. Here, we identify BTG1 and BTG2 (BTG1/2) as factors responsible for T cell quiescence. BTG1/2-deficient T cells show an increased proliferation and spontaneous activation due to a global increase in messenger RNA (mRNA) abundance, which reduces the threshold to activation. BTG1/2 deficiency leads to an increase in polyadenylate tail length, resulting in a greater mRNA half-life. Thus, BTG1/2 promote the deadenylation and degradation of mRNA to secure T cell quiescence. Our study reveals a key mechanism underlying T cell quiescence and suggests that low mRNA abundance is a crucial feature for maintaining quiescence.","journal":"Science","year":2020,"id":50046,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":213,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9556,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":66180,"name":"Jaechul Lim","orcid":"0000-0002-6075-2656","position":1,"is_corresponding":false},{"id":244721,"name":"Zhibin Yu","orcid":"0000-0002-5128-8142","position":2,"is_corresponding":false},{"id":229254,"name":"Philip Kong","orcid":null,"position":3,"is_corresponding":false},{"id":244722,"name":"Esen Sefik","orcid":"0000-0002-6807-3498","position":4,"is_corresponding":false},{"id":244723,"name":"Hao Xu","orcid":"0000-0002-2767-3665","position":5,"is_corresponding":false},{"id":244724,"name":"Christian C. D. Harman","orcid":"0000-0003-4758-8836","position":6,"is_corresponding":false},{"id":244725,"name":"Lark Kyun Kim","orcid":"0000-0001-5983-4470","position":7,"is_corresponding":false},{"id":244726,"name":"Gap Ryol Lee","orcid":"0000-0002-6412-9482","position":8,"is_corresponding":false},{"id":244727,"name":"Huabing Li","orcid":"0000-0003-3573-6803","position":9,"is_corresponding":false},{"id":80236,"name":"Richard A. Flavell","orcid":"0000-0003-4461-0778","position":10,"is_corresponding":false},{"id":244720,"name":"Soo Seok Hwang","orcid":"0000-0002-1635-4191","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-18T20:38:25.860949Z","pmid":"32165587","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}