{"doi":"10.1126/science.aau9263","title":"A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation","abstract":"<jats:title>ER-phagy keeps cells healthy</jats:title>\n                  <jats:p>\n                    In eukaryotic cells, about one-third of all proteins are targeted to the endoplasmic reticulum (ER), which serves as a hub for secretory protein traffic and quality control. Cui\n                    <jats:italic>et al.</jats:italic>\n                    studied a protein known as Lst1 in yeast and SEC24C in mammalian cells that is involved in loading secretory cargo into vesicles that are delivered to the Golgi complex. In response to stress caused by starvation or misfolded aggregate-prone secretory proteins, Lst1 acted to promote an additional function—ER-phagy. Together with autophagy receptors on the ER, Lst1 targeted ER domains for degradation to avert protein aggregation, thus preserving cellular health.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Science</jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6448\" page=\"53\" related-article-type=\"in-this-issue\" vol=\"365\" xlink:href=\"10.1126/science.aau9263\">53</jats:related-article>\n                  </jats:p>","journal":"Science","year":2019,"id":16557,"datarank":4.729360755695021,"base_score":5.075173815233827,"endowment":5.075173815233827,"self_citation_contribution":0.7612760722850741,"citation_network_contribution":3.9680846834099466,"self_endowment_contribution":0.7612760722850741,"citer_contribution":3.9680846834099466,"corpus_percentile":null,"corpus_rank":null,"citation_count":159,"citer_count":140,"citers_with_citation_signal":121,"citers_with_endowment":121,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":121768,"name":"Smriti Parashar","orcid":"0000-0002-6348-2612","position":1,"is_corresponding":false},{"id":121769,"name":"Muhammad Zahoor","orcid":"0000-0003-2108-885X","position":2,"is_corresponding":false},{"id":121770,"name":"Patrick G. Needham","orcid":"0000-0002-1674-7411","position":3,"is_corresponding":false},{"id":121771,"name":"Muriel Mari","orcid":null,"position":4,"is_corresponding":false},{"id":121772,"name":"Ming Zhu","orcid":null,"position":5,"is_corresponding":false},{"id":121773,"name":"Shuliang Chen","orcid":"0000-0002-7175-7604","position":6,"is_corresponding":false},{"id":121774,"name":"Hsuan-Chung Ho","orcid":"0000-0001-9539-6121","position":7,"is_corresponding":false},{"id":121775,"name":"Fulvio Reggiori","orcid":null,"position":8,"is_corresponding":false},{"id":121776,"name":"Hesso Farhan","orcid":null,"position":9,"is_corresponding":false},{"id":121777,"name":"Jeffrey L. Brodsky","orcid":"0000-0002-6984-8486","position":10,"is_corresponding":false},{"id":121778,"name":"Susan Ferro-Novick","orcid":"0000-0001-8714-7352","position":11,"is_corresponding":false},{"id":121767,"name":"Yixian Cui","orcid":"0000-0001-8260-1421","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.075173815233827,"endowment":5.075173815233827,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31273116","pmcid":"PMC7062386","openalex_id":"https://openalex.org/W2955889508","authors":[],"funders":[{"funder_name":"National Institute of General Medical Sciences","grant_id":"1R01GM114111","title":null},{"funder_name":"National Institute of General Medical Sciences","grant_id":"1R01GM115422","title":null},{"funder_name":"National Institute of General Medical Sciences","grant_id":"1R01GM75061","title":null},{"funder_name":"National Institute of 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HHS","grant_id":"R01 GM115422","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM075061","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM114111","title":null},{"funder_name":"National Institutes of Health","grant_id":"5P30DK079307-13","title":"Pittsburgh Center for Kidney Research"},{"funder_name":"National Institutes of Health","grant_id":"5P30DK079307-08","title":"Administrative Core"},{"funder_name":"National Institutes of Health","grant_id":"3R35GM131681-03S1","title":"The diverse roles of ER-Golgi trafficking machinery in autophagy and ER quality control"},{"funder_name":"National Institutes of Health","grant_id":"5R01GM115422-02","title":"The contribution of the secretory pathway to macroautophagy"},{"funder_name":"National Institutes of Health","grant_id":"1R01GM075061-01A1","title":"ER Associated Degradation of Membrane Proteins in Yeast"},{"funder_name":"National Institutes of Health","grant_id":"5R01GM114111-04","title":"The role of a CK1 kinase in 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