{"doi":"10.1126/science.aau1783","title":"Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells","abstract":"<jats:title>Imaging chromatin spatial organization</jats:title>\n                  <jats:p>\n                    The genome is organized within the nucleus as three-dimensional domains that modulate DNA-templated processes. Bintu\n                    <jats:italic>et al.</jats:italic>\n                    used high-throughput Oligopaint labeling and imaging to observe chromatin dynamics inside the nuclei of several different mammalian cell lines. After combining the datasets, single-cell matrices revealed chromatin arranged in topologically associating domains (TADs). Removing cohesin resulted in a loss of aggregate TADs among populations of cells, but specific TADs were still detected at the single-cell level. Furthermore, higher-order organization was detected, suggestive of cooperative interactions within the genome.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Science</jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126/science.aau1783\">eaau1783</jats:related-article>\n                  </jats:p>","journal":"Science","year":2018,"id":590145,"datarank":10.061129711573374,"base_score":6.983789965258135,"endowment":6.983789965258135,"self_citation_contribution":1.0475684947887203,"citation_network_contribution":9.013561216784653,"self_endowment_contribution":1.0475684947887203,"citer_contribution":9.013561216784653,"corpus_percentile":null,"corpus_rank":null,"citation_count":1078,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":645716,"name":"Leslie J. Mateo","orcid":"0000-0001-7110-3187","position":1,"is_corresponding":false},{"id":110153,"name":"Jun-Han Su","orcid":"0000-0001-9270-175X","position":2,"is_corresponding":false},{"id":13165,"name":"Nicholas A. Sinnott-Armstrong","orcid":"0000-0003-4490-0601","position":3,"is_corresponding":false},{"id":1231129,"name":"Mirae Baichoo","orcid":"0000-0002-4219-9076","position":4,"is_corresponding":false},{"id":89985,"name":"Seon Kinrot","orcid":"0000-0001-5614-0983","position":5,"is_corresponding":false},{"id":314342,"name":"Kei Yamaya","orcid":"0000-0002-8343-8969","position":6,"is_corresponding":false},{"id":191574,"name":"Alistair N. Boettiger","orcid":"0000-0002-3554-5196","position":7,"is_corresponding":false},{"id":3627,"name":"Xiaowei Zhuang","orcid":"0000-0002-6034-7853","position":8,"is_corresponding":false},{"id":110155,"name":"Bogdan Bintu","orcid":"0000-0001-9096-5858","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells","abstract":"<jats:title>Imaging chromatin spatial organization</jats:title>\n                  <jats:p>\n                    The genome is organized within the nucleus as three-dimensional domains that modulate DNA-templated processes. Bintu\n                    <jats:italic>et al.</jats:italic>\n                    used high-throughput Oligopaint labeling and imaging to observe chromatin dynamics inside the nuclei of several different mammalian cell lines. After combining the datasets, single-cell matrices revealed chromatin arranged in topologically associating domains (TADs). Removing cohesin resulted in a loss of aggregate TADs among populations of cells, but specific TADs were still detected at the single-cell level. Furthermore, higher-order organization was detected, suggestive of cooperative interactions within the genome.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Science</jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126/science.aau1783\">eaau1783</jats:related-article>\n                  </jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30361340","pmcid":"PMC6535145","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"R35GM122487","title":null},{"funder_name":"Burroughs Wellcome Fund","grant_id":"CASI","title":null},{"funder_name":"Chicago Community Trust","grant_id":"Searle Scholar","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"U19 MH114830","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM008313","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":6,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://science.sciencemag.org/content/sci/362/6413/eaau1783.full.pdf","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1126/science.aau1783","host_type":"publisher"},{"url":"https://www.science.org/doi/pdf/10.1126/science.aau1783","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["HCT116 Cells","Chromatin","Humans","Cell Cycle Proteins","Chromosomal Proteins, Non-Histone","In Situ Hybridization, Fluorescence","Protein Binding","Genome, Human","Single-Cell Analysis","Protein Domains","CCCTC-Binding Factor","Cohesins"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T13:54:05.393804Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}