{"doi":"10.1126/science.aaq1723","title":"Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics","abstract":"Flatworms of the species <i>Schmidtea mediterranea</i> are immortal-adult animals contain a large pool of pluripotent stem cells that continuously differentiate into all adult cell types. Therefore, single-cell transcriptome profiling of adult animals should reveal mature and progenitor cells. By combining perturbation experiments, gene expression analysis, a computational method that predicts future cell states from transcriptional changes, and a lineage reconstruction method, we placed all major cell types onto a single lineage tree that connects all cells to a single stem cell compartment. We characterized gene expression changes during differentiation and discovered cell types important for regeneration. Our results demonstrate the importance of single-cell transcriptome analysis for mapping and reconstructing fundamental processes of developmental and regenerative biology at high resolution.","journal":"Science","year":2018,"id":7641,"datarank":0.9377855824748834,"base_score":6.251903883165888,"endowment":6.251903883165888,"self_citation_contribution":0.9377855824748834,"citation_network_contribution":0.0,"self_endowment_contribution":0.9377855824748834,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":518,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0887,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2018-05-25","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":36621,"name":"Jordi Solana","orcid":"0000-0002-6770-3929","position":1,"is_corresponding":false},{"id":3587,"name":"Francesca Finotello","orcid":"0000-0003-0712-4658","position":2,"is_corresponding":false},{"id":68823,"name":"Salah Ayoub","orcid":"0000-0001-5043-8922","position":3,"is_corresponding":false},{"id":68824,"name":"Aristotelis Misios","orcid":null,"position":4,"is_corresponding":false},{"id":68825,"name":"Petar Glažar","orcid":"0000-0003-0842-0088","position":5,"is_corresponding":false},{"id":68826,"name":"Benedikt Obermayer","orcid":"0000-0002-9116-630X","position":6,"is_corresponding":false},{"id":42,"name":"Fabian Joachim Theis","orcid":"0000-0002-2419-1943","position":7,"is_corresponding":false},{"id":17156,"name":"Christine Kocks","orcid":"0000-0003-1749-3334","position":8,"is_corresponding":false},{"id":17158,"name":"Nikolaus Rajewsky","orcid":"0000-0002-4785-4332","position":9,"is_corresponding":false},{"id":36620,"name":"Mireya Plass","orcid":"0000-0002-9891-2723","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}