{"doi":"10.1126/science.aao4750","title":"Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq","abstract":"Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and cellular context in tumorigenesis. Although the genetics of H3K27M-glioma are well characterized, their cellular architecture remains uncharted. We performed single-cell RNA sequencing in 3321 cells from six primary H3K27M-glioma and matched models. We found that H3K27M-glioma primarily contain cells that resemble oligodendrocyte precursor cells (OPC-like), whereas more differentiated malignant cells are a minority. OPC-like cells exhibit greater proliferation and tumor-propagating potential than their more differentiated counterparts and are at least in part sustained by <i>PDGFRA</i> signaling. Our study characterizes oncogenic and developmental programs in H3K27M-glioma at single-cell resolution and across genetic subclones, suggesting potential therapeutic targets in this disease.","journal":"Science","year":2018,"id":7607,"datarank":0.9887510598012988,"base_score":6.591673732008658,"endowment":6.591673732008658,"self_citation_contribution":0.9887510598012988,"citation_network_contribution":0.0,"self_endowment_contribution":0.9887510598012988,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":728,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0683,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2018-04-20","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":2735,"name":"Itay Tirosh","orcid":"0000-0001-5477-2987","position":1,"is_corresponding":false},{"id":5511,"name":"Volker Hovestadt","orcid":"0000-0002-3480-6649","position":2,"is_corresponding":false},{"id":11412,"name":"Leah E. 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