{"doi":"10.1126/science.aah6752","title":"TZAP: A telomere-associated protein involved in telomere length control","abstract":"<jats:title>A protein to trim too-long telomeres</jats:title>\n                  <jats:p>\n                    Telomeres cap the ends of linear eukaryotic chromosomes. They consist of multiple copies of short DNA repeats. The length of telomeres is important to genome stability; if they become too short, individuals can become prone to cancer and premature aging. Li\n                    <jats:italic>et al.</jats:italic>\n                    discovered a protein, TZAP (telomeric zinc finger–associated protein), which instead prevents telomeres from becoming too long (see the Perspective by Lossaint and Lingner). TZAP binds directly to the telomeric DNA repeats, competing with the shelterin complex. It stimulates telomere trimming, preventing aberrantly long telomeres.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Science</jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6325\" page=\"638\" related-article-type=\"in-this-issue\" vol=\"355\" xlink:href=\"10.1126/science.aah6752\">638</jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6325\" page=\"578\" related-article-type=\"in-this-issue\" vol=\"355\" xlink:href=\"10.1126/science.aam7015\">578</jats:related-article>\n                  </jats:p>","journal":"Science","year":2017,"id":46539,"datarank":8.386639578145694,"base_score":5.25227342804663,"endowment":5.25227342804663,"self_citation_contribution":0.7878410142069946,"citation_network_contribution":7.598798563938699,"self_endowment_contribution":0.7878410142069946,"citer_contribution":7.598798563938699,"corpus_percentile":null,"corpus_rank":null,"citation_count":190,"citer_count":156,"citers_with_citation_signal":131,"citers_with_endowment":131,"datacite_reuse_total":25,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":215679,"name":"Javier Miralles Fusté","orcid":"0000-0001-8818-9650","position":1,"is_corresponding":false},{"id":215680,"name":"Tatevik Simavorian","orcid":"0000-0001-8917-6245","position":2,"is_corresponding":false},{"id":215681,"name":"Cristina Bartocci","orcid":null,"position":3,"is_corresponding":false},{"id":215682,"name":"Jill Tsai","orcid":null,"position":4,"is_corresponding":false},{"id":215683,"name":"Jan Karlseder","orcid":null,"position":5,"is_corresponding":false},{"id":215684,"name":"Eros Lazzerini Denchi","orcid":"0000-0001-5378-4644","position":6,"is_corresponding":false},{"id":215678,"name":"Julia Su Zhou Li","orcid":"0000-0003-2737-4187","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"TZAP: A telomere-associated protein involved in telomere length control","abstract":"<jats:title>A protein to trim too-long telomeres</jats:title>\n                  <jats:p>\n                    Telomeres cap the ends of linear eukaryotic chromosomes. They consist of multiple copies of short DNA repeats. The length of telomeres is important to genome stability; if they become too short, individuals can become prone to cancer and premature aging. Li\n                    <jats:italic>et al.</jats:italic>\n                    discovered a protein, TZAP (telomeric zinc finger–associated protein), which instead prevents telomeres from becoming too long (see the Perspective by Lossaint and Lingner). TZAP binds directly to the telomeric DNA repeats, competing with the shelterin complex. It stimulates telomere trimming, preventing aberrantly long telomeres.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Science</jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6325\" page=\"638\" related-article-type=\"in-this-issue\" vol=\"355\" xlink:href=\"10.1126/science.aah6752\">638</jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6325\" page=\"578\" related-article-type=\"in-this-issue\" vol=\"355\" xlink:href=\"10.1126/science.aam7015\">578</jats:related-article>\n                  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CA014195","title":null}],"total_grants":4,"fwci":11.9694,"citation_percentile":0.99077933,"influential_citations":7,"citation_trend":[{"year":2017,"count":23},{"year":2018,"count":20},{"year":2019,"count":13},{"year":2020,"count":20},{"year":2021,"count":20},{"year":2022,"count":18},{"year":2023,"count":22},{"year":2024,"count":35},{"year":2025,"count":14},{"year":2026,"count":4}],"oa_status":"closed","license":"http://www.sciencemag.org/about/science-licenses-journal-article-reuse","oa_locations":[{"url":"https://europepmc.org/articles/pmc5518674?pdf=render","host_type":"GREEN"},{"url":"https://www.science.org/doi/pdf/10.1126/science.aah6752","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.aah6752","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28082411","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5518674","host_type":"repository"}],"fields_of_study":["Telomeres, Telomerase, and Senescence","Mitochondrial Function and Pathology","Chromosomal and Genetic Variations","Medicine","Biology","Cell Line, Tumor","DNA-Binding Proteins","Gene Knockout Techniques","Humans","Protein Binding","Tandem Repeat Sequences","Telomere","Telomere Homeostasis","Telomeric Repeat Binding Protein 1","Telomeric Repeat Binding Protein 2","Transcription Factors","Zinc Fingers"],"mesh_terms":["DNA-Binding Proteins","Humans","Protein Binding","Transcription Factors","Zinc Fingers","Telomere","Tandem Repeat Sequences","Telomeric Repeat Binding Protein 1","Telomeric Repeat Binding Protein 2","Cell Line, Tumor","Gene Knockout Techniques","Telomere Homeostasis"],"keywords":["Telomere","Shelterin","Telomere-binding protein","Biology","Telomerase","Eukaryotic chromosome fine structure","DNA","Genetics","Zinc finger","DNA-binding protein","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.24792420.v1","title":"Additional file 2 of The genetics of gaits in Icelandic horses 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