{"doi":"10.1126/science.aah4573","title":"Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors","abstract":"Dendritic cells (DCs) and monocytes play a central role in pathogen sensing, phagocytosis, and antigen presentation and consist of multiple specialized subtypes. However, their identities and interrelationships are not fully understood. Using unbiased single-cell RNA sequencing (RNA-seq) of ~2400 cells, we identified six human DCs and four monocyte subtypes in human blood. Our study reveals a new DC subset that shares properties with plasmacytoid DCs (pDCs) but potently activates T cells, thus redefining pDCs; a new subdivision within the CD1C<sup>+</sup> subset of DCs; the relationship between blastic plasmacytoid DC neoplasia cells and healthy DCs; and circulating progenitor of conventional DCs (cDCs). Our revised taxonomy will enable more accurate functional and developmental analyses as well as immune monitoring in health and disease.","journal":"Science","year":2017,"id":11844,"datarank":12.409844621354079,"base_score":7.807916628926408,"endowment":7.807916628926408,"self_citation_contribution":1.1711874943389615,"citation_network_contribution":11.238657127015117,"self_endowment_contribution":1.1711874943389615,"citer_contribution":11.238657127015117,"corpus_percentile":82.4,"corpus_rank":2513,"citation_count":2459,"citer_count":173,"citers_with_citation_signal":173,"citers_with_endowment":173,"datacite_reuse_total":0,"is_dataset":false,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2017-04-21","authors":[{"id":167,"name":"Rahul Satija","orcid":"0000-0002-1479-664X","position":1,"is_corresponding":false},{"id":36230,"name":"Gary Reynolds","orcid":"0000-0002-8142-8708","position":2,"is_corresponding":false},{"id":44969,"name":"Siranush Sarkizova","orcid":"0000-0003-2530-8610","position":3,"is_corresponding":false},{"id":20632,"name":"Karthik Shekhar","orcid":"0000-0003-4349-6600","position":4,"is_corresponding":false},{"id":49853,"name":"James Fletcher","orcid":"0000-0001-9610-1858","position":5,"is_corresponding":false},{"id":95186,"name":"Morgane Griesbeck","orcid":"0000-0003-4962-102X","position":6,"is_corresponding":false},{"id":159,"name":"Andrew Butler","orcid":"0000-0003-3608-0463","position":7,"is_corresponding":false},{"id":52007,"name":"Shiwei Zheng","orcid":"0000-0001-6682-6743","position":8,"is_corresponding":false},{"id":95187,"name":"Suzan Lazo","orcid":"0000-0002-6678-9847","position":9,"is_corresponding":false},{"id":36226,"name":"Laura Jardine","orcid":"0000-0003-4495-8205","position":10,"is_corresponding":false},{"id":36268,"name":"David Dixon","orcid":"0000-0002-5904-9074","position":11,"is_corresponding":false},{"id":36233,"name":"Emily Stephenson","orcid":"0000-0002-4244-4019","position":12,"is_corresponding":false},{"id":95188,"name":"Emil Nilsson","orcid":"0000-0001-8338-8124","position":13,"is_corresponding":false},{"id":95189,"name":"Ida Grundberg","orcid":"0000-0002-8997-3962","position":14,"is_corresponding":false},{"id":36269,"name":"David McDonald","orcid":"0000-0002-2410-9364","position":15,"is_corresponding":false},{"id":36266,"name":"Andrew Filby","orcid":"0000-0001-9078-4360","position":16,"is_corresponding":false},{"id":15887,"name":"Weibo Li","orcid":"0000-0002-0065-8166","position":17,"is_corresponding":false},{"id":771,"name":"Philip L. De Jager","orcid":"0000-0002-8057-2505","position":18,"is_corresponding":false},{"id":75579,"name":"Andrew A. Lane","orcid":"0000-0001-7380-0226","position":20,"is_corresponding":false},{"id":11454,"name":"Muzlifah Haniffa","orcid":"0000-0002-3927-2084","position":21,"is_corresponding":false},{"id":29633,"name":"Prisca Liberali","orcid":"0000-0003-0695-6081","position":22,"is_corresponding":false},{"id":409,"name":"Nir Hacohen","orcid":"0000-0002-2349-2656","position":23,"is_corresponding":false},{"id":2697,"name":"Orit Rozenblatt–Rosen","orcid":"0000-0001-6313-3570","position":24,"is_corresponding":false},{"id":14837,"name":"Alexandra–Chloé Villani","orcid":"0000-0001-7461-0408","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}