{"doi":"10.1126/science.aad3439","title":"Visualizing antibody affinity maturation in germinal centers","abstract":"<jats:title>Diversity reigns in antibody responses</jats:title>\n                  <jats:p>\n                    During the course of an immune response, B cells specific for an invading pathogen divide. The antibodies they produce increase in affinity via somatic mutation in specialized lymph node structures called germinal centers. Tas\n                    <jats:italic>et al.</jats:italic>\n                    used multiphoton microscopy and sequencing to determine how different B cell clones compete with one another within mouse germinal centers. Multiple B cell clones can seed individual germinal centers, and germinal centers lose diversity at disparate rates. Such heterogeneity suggests that manipulating minor clonal populations to gain an advantage during vaccination may one day be possible.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Science</jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6277\" page=\"1048\" related-article-type=\"in-this-issue\" vol=\"351\" xlink:href=\"10.1126/science.aad3439\">1048</jats:related-article>\n                  </jats:p>","journal":"Science","year":2016,"id":611522,"datarank":0.9333864402107055,"base_score":6.222576268071369,"endowment":6.222576268071369,"self_citation_contribution":0.9333864402107055,"citation_network_contribution":0.0,"self_endowment_contribution":0.9333864402107055,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":503,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":295162,"name":"Luka Mesin","orcid":"0000-0001-9852-6841","position":1,"is_corresponding":false},{"id":989455,"name":"Giulia Pasqual","orcid":"0000-0002-1476-2669","position":2,"is_corresponding":false},{"id":24088,"name":"Sasha Targ","orcid":"0009-0006-1510-2589","position":3,"is_corresponding":false},{"id":630610,"name":"Johanne T. Jacobsen","orcid":"0000-0001-9757-1923","position":4,"is_corresponding":false},{"id":1573849,"name":"Yasuko M. Mano","orcid":null,"position":5,"is_corresponding":false},{"id":1573851,"name":"Casie S. Chen","orcid":null,"position":6,"is_corresponding":false},{"id":1573853,"name":"Jean-Claude Weill","orcid":null,"position":7,"is_corresponding":false},{"id":1573855,"name":"Claude-Agnès Reynaud","orcid":null,"position":8,"is_corresponding":false},{"id":233489,"name":"Edward P. Browne","orcid":"0000-0001-9070-7015","position":9,"is_corresponding":false},{"id":1573858,"name":"Michael Meyer-Hermann","orcid":null,"position":10,"is_corresponding":false},{"id":266895,"name":"Gabriel D. Victora","orcid":"0000-0001-8807-348X","position":11,"is_corresponding":false},{"id":1573843,"name":"Jeroen M. J. Tas","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Visualizing antibody affinity maturation in germinal centers","abstract":"<jats:title>Diversity reigns in antibody responses</jats:title>\n                  <jats:p>\n                    During the course of an immune response, B cells specific for an invading pathogen divide. The antibodies they produce increase in affinity via somatic mutation in specialized lymph node structures called germinal centers. Tas\n                    <jats:italic>et al.</jats:italic>\n                    used multiphoton microscopy and sequencing to determine how different B cell clones compete with one another within mouse germinal centers. Multiple B cell clones can seed individual germinal centers, and germinal centers lose diversity at disparate rates. Such heterogeneity suggests that manipulating minor clonal populations to gain an advantage during vaccination may one day be possible.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Science</jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6277\" page=\"1048\" related-article-type=\"in-this-issue\" vol=\"351\" xlink:href=\"10.1126/science.aad3439\">1048</jats:related-article>\n                  </jats:p>","is_dataset_classified":null,"base_score":6.222576268071369,"endowment":6.222576268071369,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26912368","pmcid":"PMC4938154","openalex_id":"https://openalex.org/W2277351499","authors":[],"funders":[{"funder_name":"Human Frontier Science Program","grant_id":"RGP0033/2015","title":null},{"funder_name":"NIH","grant_id":"5DP5OD012146","title":null},{"funder_name":"NIH","grant_id":"S10 OD016326","title":null},{"funder_name":"NIH HHS","grant_id":"DP5 OD012146","title":null},{"funder_name":"Norwegian Research Council","grant_id":"","title":null},{"funder_name":"Swiss National Science Foundation","grant_id":"","title":null},{"funder_name":"German Federal Ministry of Education and Research","grant_id":"","title":null}],"total_grants":7,"fwci":41.4087,"citation_percentile":0.99934768,"influential_citations":0,"citation_trend":[{"year":2016,"count":14},{"year":2017,"count":51},{"year":2018,"count":55},{"year":2019,"count":39},{"year":2020,"count":53},{"year":2021,"count":80},{"year":2022,"count":46},{"year":2023,"count":50},{"year":2024,"count":44},{"year":2025,"count":40},{"year":2026,"count":30}],"oa_status":"green","license":"http://www.sciencemag.org/about/science-licenses-journal-article-reuse","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4938154","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4938154","host_type":"repository"},{"url":"https://www.science.org/doi/pdf/10.1126/science.aad3439","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.aad3439","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26912368","host_type":"repository"},{"url":"http://hdl.handle.net/10033/609125","host_type":"repository"},{"url":"http://hdl.handle.net/11577/3309932","host_type":"repository"}],"fields_of_study":["Monoclonal and Polyclonal Antibodies Research","CAR-T cell therapy research","T-cell and B-cell Immunology","Animals","Antibodies","Antibody Affinity","B-Lymphocytes","Germinal Center","HIV-1","Humans","Mice","Microscopy, Fluorescence, Multiphoton","Molecular Imaging","Orthomyxoviridae","Sequence Analysis, DNA","Single-Cell Analysis"],"mesh_terms":["Animals","Antibodies","Antibody Affinity","B-Lymphocytes","Humans","Orthomyxoviridae","HIV-1","Sequence Analysis, DNA","Germinal Center","Microscopy, Fluorescence, Multiphoton","Mice","Molecular Imaging","Single-Cell Analysis"],"keywords":["Germinal center","Antibody","Affinity maturation","Chemistry","Biology","Immunology","B cell"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T20:19:00.260708Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}