{"doi":"10.1126/science.aaa7257","title":"Comment on “Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling”","abstract":"<jats:p>\n            Jan\n            <jats:italic>et al</jats:italic>\n            . (Research Articles, 7 November 2014, p. 716) propose that ribosomes translating secretome messenger RNAs (mRNAs) traffic from the cytosol to the endoplasmic reticulum (ER) upon emergence of the signal peptide and return to the cytosol after termination. An accounting of controls demonstrates that mRNAs initiate translation on ER-bound ribosomes and that ribosomes are retained on the ER through many cycles of translation.\n          </jats:p>","journal":"Science","year":2015,"id":589710,"datarank":1.822642488080081,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":1.345934413527889,"self_endowment_contribution":0.47670807455219194,"citer_contribution":1.345934413527889,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":16,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":395501,"name":"Christopher V. 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An accounting of controls demonstrates that mRNAs initiate translation on ER-bound ribosomes and that ribosomes are retained on the ER through many cycles of translation.\n          </jats:p>","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26068841","pmcid":"PMC4862200","openalex_id":"https://openalex.org/W1666668357","authors":[],"funders":[{"funder_name":"U.S. National Institutes of Health","grant_id":"GM101533","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM101533","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R01GM101533-01","title":"mRNA Localization in Organelle Biogenesis"},{"funder_name":"National Institute of General Medical Sciences","grant_id":"","title":null}],"total_grants":4,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2016,"count":3},{"year":2017,"count":2},{"year":2018,"count":5},{"year":2019,"count":5},{"year":2020,"count":2},{"year":2021,"count":4},{"year":2022,"count":1}],"oa_status":"green","license":"http://www.sciencemag.org/about/science-licenses-journal-article-reuse","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4862200","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4862200","host_type":"repository"},{"url":"https://www.science.org/doi/pdf/10.1126/science.aaa7257","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.aaa7257","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26068841","host_type":"repository"},{"url":"https://science.sciencemag.org/content/sci/348/6240/1217.1.full.pdf","host_type":""},{"url":"https://dx.doi.org/10.1126/science.aaa7257","host_type":""}],"fields_of_study":["RNA and protein synthesis mechanisms","Advanced biosensing and bioanalysis techniques","RNA modifications and cancer","0301 basic medicine","0303 health sciences","03 medical and health sciences","Cells","Endoplasmic Reticulum","Humans","Mitochondria","Protein Biosynthesis","Ribosomes"],"mesh_terms":["Cells","Endoplasmic Reticulum","Humans","Mitochondria","Ribosomes","Protein Biosynthesis"],"keywords":["Chromosomal translocation","Ribosome","Ribosome profiling","Profiling (computer programming)","Computational biology","Biology","Cell biology","Genetics","RNA","Computer science","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T04:43:40.719280Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}