{"doi":"10.1126/science.aaa3761","title":"Distortion of histone octamer core promotes nucleosome mobilization by a chromatin remodeler","abstract":"<jats:title>Deformation powers the nucleosome slide</jats:title>\n                  <jats:p>\n                    In eukaryotes, DNA is packed onto nucleosomes. For transcription factors and other proteins to gain access to DNA, nucleosomes must be moved out of the way, or “remodeled”—but not disassembled. Nucleosomes are composed of histone protein octamers, the cores of which have generally been considered to be fairly rigid. Sinha\n                    <jats:italic>et al.</jats:italic>\n                    used nuclear magnetic resonance and protein cross-linking to show that one of the enzyme complexes that remodel nucleosomes, SNF2h, is able to distort the histone octamer (see the Perspective by Flaus and Owen-Hughes). Nucleosome deformation was important for this remodeler to be able to slide nucleosomes out of the way.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Science</jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" related-article-type=\"in-this-issue\" xlink:href=\"10.1126/science.aaa3761\">10.1126/science.aaa3761</jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6322\" page=\"245\" related-article-type=\"in-this-issue\" vol=\"355\" xlink:href=\"10.1126/science.aam5403\">245</jats:related-article>\n                  </jats:p>","journal":"Science","year":2017,"id":603251,"datarank":0.7168685239667295,"base_score":4.77912349311153,"endowment":4.77912349311153,"self_citation_contribution":0.7168685239667295,"citation_network_contribution":0.0,"self_endowment_contribution":0.7168685239667295,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":118,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":366460,"name":"John D. Gross","orcid":"0000-0002-1377-4705","position":1,"is_corresponding":false},{"id":6711,"name":"Geeta J. Narlikar","orcid":"0000-0002-1920-0147","position":2,"is_corresponding":false},{"id":1171409,"name":"Kalyan K. Sinha","orcid":"0000-0001-7884-7664","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-29T21:26:08.159920Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}