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This demonstrates the involvement of LMP-7 in the MHC class I presentation pathway and suggests that LMP-7 functions as an integral part of the peptide supply machinery.</jats:p>","journal":"Science","year":1994,"id":634067,"datarank":0.9406482647787451,"base_score":6.270988431858299,"endowment":6.270988431858299,"self_citation_contribution":0.9406482647787451,"citation_network_contribution":0.0,"self_endowment_contribution":0.9406482647787451,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":528,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1644313,"name":"W. 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Mice with a targeted deletion of the gene encoding LMP-7 have reduced levels of MHC class I cell-surface expression and present the endogenous antigen HY inefficiently; addition of peptides to splenocytes deficient in LMP-7 restores wild-type class I expression levels. 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