{"doi":"10.1126/science.8016643","title":"Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA","abstract":"<jats:p>Major histocompatibility complex (MHC) class II genes are expressed constitutively in only a few cell types, but they can be induced in the majority of them, in particular by interferon-γ (IFN-γ). The MHC class II transactivator gene CIITA is defective in a form of primary MHC class II deficiency. Here it is shown that CIITA expression is controlled and induced by IFN-γ. A functional CIITA gene is necessary for class II induction, and transfection of CIITA is sufficient to activate expression of MHC class II genes in class II-negative cells in the absence of IFN-γ. CIITA is therefore a general regulator of both inducible and constitutive MHC class II expression.</jats:p>","journal":"Science","year":1994,"id":667161,"datarank":1.0210244040588266,"base_score":6.806829360392176,"endowment":6.806829360392176,"self_citation_contribution":1.0210244040588266,"citation_network_contribution":0.0,"self_endowment_contribution":1.0210244040588266,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":903,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1672937,"name":"Claire-Anne Siegrist","orcid":null,"position":1,"is_corresponding":false},{"id":1742291,"name":"Annick Mottet","orcid":null,"position":2,"is_corresponding":false},{"id":1742292,"name":"Barbara Lisowska-Grospierre","orcid":null,"position":3,"is_corresponding":false},{"id":1742294,"name":"Bernard Mach","orcid":null,"position":4,"is_corresponding":false},{"id":1710838,"name":"Viktor Steimle","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA","abstract":"<jats:p>Major histocompatibility complex (MHC) class II genes are expressed constitutively in only a few cell types, but they can be induced in the majority of them, in particular by interferon-γ (IFN-γ). The MHC class II transactivator gene CIITA is defective in a form of primary MHC class II deficiency. Here it is shown that CIITA expression is controlled and induced by IFN-γ. A functional CIITA gene is necessary for class II induction, and transfection of CIITA is sufficient to activate expression of MHC class II genes in class II-negative cells in the absence of IFN-γ. CIITA is therefore a general regulator of both inducible and constitutive MHC class II expression.</jats:p>","is_dataset_classified":null,"base_score":6.806829360392176,"endowment":6.806829360392176,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8016643","pmcid":null,"openalex_id":"https://openalex.org/W2060320549","authors":[],"funders":[],"total_grants":0,"fwci":11.3548,"citation_percentile":0.98829982,"influential_citations":0,"citation_trend":[{"year":2012,"count":29},{"year":2013,"count":13},{"year":2014,"count":18},{"year":2015,"count":21},{"year":2016,"count":26},{"year":2017,"count":19},{"year":2018,"count":20},{"year":2019,"count":21},{"year":2020,"count":26},{"year":2021,"count":33},{"year":2022,"count":38},{"year":2023,"count":50},{"year":2024,"count":42},{"year":2025,"count":37},{"year":2026,"count":23}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.8016643","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.8016643","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8016643","host_type":"repository"}],"fields_of_study":["T-cell and B-cell Immunology","Immune Response and Inflammation","Immunotherapy and Immune Responses"],"mesh_terms":["Histocompatibility Antigens Class II","Cell Line","Chromosome Mapping","Chromosomes, Human, Pair 16","Fibroblasts","Gene Expression Regulation","Genes, MHC Class II","Humans","Interferon-gamma","Models, Genetic","Nuclear Proteins","RNA, Messenger","Transfection","Tumor Cells, Cultured","Trans-Activators"],"keywords":["CIITA","CD74","MHC class II","Major histocompatibility complex","Biology","MHC class I","Transactivation","Interferon gamma","Gene","Cell biology","Gene expression","Genetics","Immune system"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T16:52:24.857105Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}