{"doi":"10.1126/science.7973666","title":"Spermine and Spermidine as Gating Molecules for Inward Rectifier K\n            <sup>+</sup>\n            Channels","abstract":"<jats:p>\n            Inward rectifier K\n            <jats:sup>+</jats:sup>\n            channels pass prominent inward currents, while outward currents are largely blocked. The inward rectification is due to block by intracellular Mg\n            <jats:sup>2+</jats:sup>\n            and a Mg\n            <jats:sup>2+</jats:sup>\n            -independent process described as intrinsic gating. The rapid loss of gating upon patch excision suggests that cytoplasmic factors participate in gating. \"Intrinsic\" gating can be restored in excised patches by nanomolar concentrations of two naturally occurring polyamines, spermine and spermidine. Spermine and spermidine may function as physiological blockers of inward rectifier K\n            <jats:sup>+</jats:sup>\n            channels and \"intrinsic\" gating may largely reflect voltage-dependent block by these cations.\n          </jats:p>","journal":"Science","year":1994,"id":686665,"datarank":0.9395097393887437,"base_score":6.263398262591624,"endowment":6.263398262591624,"self_citation_contribution":0.9395097393887437,"citation_network_contribution":0.0,"self_endowment_contribution":0.9395097393887437,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":524,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":420744,"name":"Maurizio Taglialatela","orcid":"0000-0002-8202-0560","position":1,"is_corresponding":false},{"id":1793891,"name":"Barbara A. Wible","orcid":null,"position":2,"is_corresponding":false},{"id":1793893,"name":"Charles M. Henley","orcid":null,"position":3,"is_corresponding":false},{"id":1571663,"name":"Arthur M. Brown","orcid":null,"position":4,"is_corresponding":false},{"id":1793889,"name":"Eckhard Ficker","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Spermine and Spermidine as Gating Molecules for Inward Rectifier K\n            <sup>+</sup>\n            Channels","abstract":"<jats:p>\n            Inward rectifier K\n            <jats:sup>+</jats:sup>\n            channels pass prominent inward currents, while outward currents are largely blocked. The inward rectification is due to block by intracellular Mg\n            <jats:sup>2+</jats:sup>\n            and a Mg\n            <jats:sup>2+</jats:sup>\n            -independent process described as intrinsic gating. The rapid loss of gating upon patch excision suggests that cytoplasmic factors participate in gating. \"Intrinsic\" gating can be restored in excised patches by nanomolar concentrations of two naturally occurring polyamines, spermine and spermidine. Spermine and spermidine may function as physiological blockers of inward rectifier K\n            <jats:sup>+</jats:sup>\n            channels and \"intrinsic\" gating may largely reflect voltage-dependent block by these cations.\n          </jats:p>","is_dataset_classified":null,"base_score":6.263398262591624,"endowment":6.263398262591624,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7973666","pmcid":null,"openalex_id":"https://openalex.org/W2044813037","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"HL36930","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL37044","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"NS23877","title":null}],"total_grants":3,"fwci":16.9674,"citation_percentile":0.99587005,"influential_citations":0,"citation_trend":[{"year":2012,"count":12},{"year":2013,"count":8},{"year":2014,"count":6},{"year":2015,"count":7},{"year":2016,"count":8},{"year":2017,"count":9},{"year":2018,"count":7},{"year":2019,"count":4},{"year":2020,"count":8},{"year":2021,"count":7},{"year":2022,"count":4},{"year":2023,"count":3},{"year":2024,"count":5},{"year":2025,"count":7},{"year":2026,"count":4}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.7973666","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.7973666","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7973666","host_type":"repository"}],"fields_of_study":["Ion channel regulation and function","Neuroscience and Neuropharmacology Research","Cardiac electrophysiology and arrhythmias","Animals","Diamines","Ion Channel Gating","Magnesium","Membrane Potentials","Mutagenesis","Oocytes","Patch-Clamp Techniques","Potassium Channels","Putrescine","Spermidine","Spermine","Xenopus"],"mesh_terms":["Animals","Diamines","Magnesium","Membrane Potentials","Oocytes","Putrescine","Spermidine","Spermine","Xenopus","Potassium Channels","Ion Channel Gating","Mutagenesis","Patch-Clamp Techniques"],"keywords":["Gating","Spermine","Inward-rectifier potassium ion channel","Spermidine","Biophysics","Chemistry","Polyamine","Intracellular","Biochemistry","Ion channel","Biology","Receptor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T20:08:27.984279Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}