{"doi":"10.1126/science.781840","title":"Human Malaria Parasites in Continuous Culture","abstract":"Plasmodium falciparum can now be maintained in continuous culture in human erythrocytes incubated at 38 degrees C in RPMI 1640 medium with human serum under an atmosphere with 7 percent carbon dioxide and low oxygen (1 or 5 percent). The original parasite material, derived from an infected Aotus trivirgatus monkey, was diluted more than 100 million times by the addition of human erythrocytes at 3- or 4-day intervals. The parasites continued to reproduce in their normal asexual cycle of approximately 48 hours but were no longer highly synchronous. The have remained infective to Aotus.","journal":"Science","year":1976,"id":11146,"datarank":30.71261536126524,"base_score":8.980801413573113,"endowment":8.980801413573113,"self_citation_contribution":1.347120212035967,"citation_network_contribution":29.36549514922927,"self_endowment_contribution":1.347120212035967,"citer_contribution":29.36549514922927,"corpus_percentile":98.5,"corpus_rank":1636,"citation_count":7948,"citer_count":195,"citers_with_citation_signal":195,"citers_with_endowment":195,"datacite_reuse_total":0,"is_dataset":false,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"1976-08-20","authors":[{"id":89969,"name":"James B. Jensen","orcid":null,"position":1,"is_corresponding":false},{"id":89968,"name":"William Trager","orcid":null,"position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}