{"doi":"10.1126/science.6760397","title":"Natural Antibodies to Human Retrovirus HTLV in a Cluster of Japanese Patients with Adult T Cell Leukemia","abstract":"<jats:p>Human T cell lymphoma leukemia virus (HTLV) is a human retrovirus (RNA tumor virus) that was originally isolated from a few patients with leukemias or lymphomas involving mature T lymphocytes. Here we report that the serum of Japanese patients with adult T cell leukemia, but not the serum of tested normal donors, contains high titers of antibodies to HTLV. These observations, together with data from Japan showing that adult T cell leukemia is endemic in southwest Japan, suggest that HTLV is involved in a subtype of human T cell malignancy, including Japanese adult T cell leukemia.</jats:p>","journal":"Science","year":1982,"id":40395,"datarank":22.875438126389888,"base_score":5.8944028342648505,"endowment":5.8944028342648505,"self_citation_contribution":0.8841604251397277,"citation_network_contribution":21.99127770125016,"self_endowment_contribution":0.8841604251397277,"citer_contribution":21.99127770125016,"corpus_percentile":null,"corpus_rank":null,"citation_count":362,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":196368,"name":"Yoshinobu Nakao","orcid":null,"position":1,"is_corresponding":false},{"id":196369,"name":"Kunihiro Notake","orcid":null,"position":2,"is_corresponding":false},{"id":196370,"name":"Yohei Ito","orcid":null,"position":3,"is_corresponding":false},{"id":196371,"name":"Ann Sliski","orcid":null,"position":4,"is_corresponding":false},{"id":116896,"name":"Robert C. Gallo","orcid":null,"position":5,"is_corresponding":false},{"id":153259,"name":"Marjorie Robert-Guroff","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.8944028342648505,"endowment":5.8944028342648505,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6760397","pmcid":null,"openalex_id":"https://openalex.org/W2005988457","authors":[],"funders":[],"total_grants":0,"fwci":31.1777,"citation_percentile":0.99838288,"influential_citations":6,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":2},{"year":2017,"count":3},{"year":2019,"count":1},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.6760397","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.6760397","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6760397","host_type":"repository"}],"fields_of_study":["T-cell and Retrovirus Studies","Vector-Borne Animal Diseases","Animal Disease Management and Epidemiology","Biology","Medicine","Antibodies, Viral","Antibody Specificity","Fluorescent Antibody Technique","Humans","Japan","Leukemia","Radioimmunoassay","Retroviridae","T-Lymphocytes"],"mesh_terms":["Antibodies, Viral","Antibody Specificity","Fluorescent Antibody Technique","Humans","Japan","Leukemia","Radioimmunoassay","Retroviridae","T-Lymphocytes"],"keywords":["Retrovirus","Leukemia","Virology","T-cell leukemia","Lymphoma","Virus","Antibody","Titer","Deltaretrovirus","Biology","Immunology","Malignancy","T cell","Medicine","Viral disease","Immune system","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-12T05:34:49.801655Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}