{"doi":"10.1126/science.6541807","title":"Separation of Morphine Analgesia from Physical Dependence","abstract":"<jats:p>Intravenous infusion of morphine sulfate in rats for 24 hours produced marked opioid dependence, manifested by a series of well-documented signs appearing after injection of the opiate antagonist naloxone. Treatment of rats with naloxonazine significantly reduced the analgesia associated with the morphine infusions for more than 24 hours. Furthermore, 14 of 16 withdrawal signs observed in naloxonazine-treated rats were virtually identical to those in rats that received morphine alone. These results raise the possibility that different receptor mechanisms mediate morphine analgesia and many of the withdrawal signs associated with morphine dependence.</jats:p>","journal":"Science","year":1984,"id":640186,"datarank":0.7266280629687888,"base_score":4.844187086458591,"endowment":4.844187086458591,"self_citation_contribution":0.7266280629687888,"citation_network_contribution":0.0,"self_endowment_contribution":0.7266280629687888,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":126,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1663769,"name":"Janet M. 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Furthermore, 14 of 16 withdrawal signs observed in naloxonazine-treated rats were virtually identical to those in rats that received morphine alone. These results raise the possibility that different receptor mechanisms mediate morphine analgesia and many of the withdrawal signs associated with morphine dependence.</jats:p>","is_dataset_classified":null,"base_score":4.844187086458591,"endowment":4.844187086458591,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6541807","pmcid":null,"openalex_id":"https://openalex.org/W2039764726","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"NS 00415","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"DA 002615","title":null}],"total_grants":2,"fwci":2.2942,"citation_percentile":0.89053592,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":5},{"year":2014,"count":5},{"year":2015,"count":3},{"year":2016,"count":2},{"year":2017,"count":6},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":4},{"year":2022,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.6541807","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.6541807","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6541807","host_type":"repository"}],"fields_of_study":["Neuropeptides and Animal Physiology","Pain Mechanisms and Treatments","Receptor Mechanisms and Signaling","Analgesia","Animals","Humans","Male","Morphine","Naloxone","Rats","Rats, Inbred Strains","Substance Withdrawal Syndrome","Substance-Related Disorders"],"mesh_terms":["Analgesia","Animals","Humans","Male","Morphine","Naloxone","Rats, Inbred Strains","Substance Withdrawal Syndrome","Substance-Related Disorders","Rats"],"keywords":["Morphine","(+)-Naloxone","Morphine sulfate","Physical dependence","Medicine","Antagonist","Anesthesia","Opioid","Opiate","Pharmacology","Receptor","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T07:36:55.982641Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}