{"doi":"10.1126/science.432648","title":"Iron Deficiency Prevents Liver Toxicity of 2,3,7,8-Tetrachlorodibenzo-\n            <i>p</i>\n            -Dioxin","abstract":"<jats:p>\n            The compound 2,3,7,8-tetrachlorodibenzo-\n            <jats:italic>p</jats:italic>\n            -dioxin (TCDD) causes hepatocellular damage and porphyria in C57B1/6J mice, among a wide range of toxic effects. We compared the effect of TCDD toxicity in iron-deficient mice with that in mice receiving a normal diet. Porphyria did not develop in the iron-deficient animals, and these animals were also protected from hepatocellular damage and certain other toxic effects of TCDD.\n          </jats:p>","journal":"Science","year":1979,"id":622937,"datarank":0.7104297672591745,"base_score":4.736198448394496,"endowment":4.736198448394496,"self_citation_contribution":0.7104297672591745,"citation_network_contribution":0.0,"self_endowment_contribution":0.7104297672591745,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":113,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1609768,"name":"K. G. Jones","orcid":null,"position":1,"is_corresponding":false},{"id":1609769,"name":"F. M. Cole","orcid":null,"position":2,"is_corresponding":false},{"id":1609770,"name":"D. Basford","orcid":null,"position":3,"is_corresponding":false},{"id":1609771,"name":"F. Krestynski","orcid":null,"position":4,"is_corresponding":false},{"id":1609766,"name":"G. D. Sweeny","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Iron Deficiency Prevents Liver Toxicity of 2,3,7,8-Tetrachlorodibenzo-\n            <i>p</i>\n            -Dioxin","abstract":"<jats:p>\n            The compound 2,3,7,8-tetrachlorodibenzo-\n            <jats:italic>p</jats:italic>\n            -dioxin (TCDD) causes hepatocellular damage and porphyria in C57B1/6J mice, among a wide range of toxic effects. We compared the effect of TCDD toxicity in iron-deficient mice with that in mice receiving a normal diet. Porphyria did not develop in the iron-deficient animals, and these animals were also protected from hepatocellular damage and certain other toxic effects of TCDD.\n          </jats:p>","is_dataset_classified":null,"base_score":4.736198448394496,"endowment":4.736198448394496,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"432648","pmcid":null,"openalex_id":"https://openalex.org/W2063373861","authors":[],"funders":[],"total_grants":0,"fwci":8.1468,"citation_percentile":0.97928654,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2017,"count":2},{"year":2020,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.432648","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.432648","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/432648","host_type":"repository"}],"fields_of_study":["Pharmacogenetics and Drug Metabolism","Porphyrin Metabolism and Disorders","Drug Transport and Resistance Mechanisms","Animals","Dioxins","Enzyme Induction","Iron Deficiencies","Liver","Mice","Microsomes, Liver","Mixed Function Oxygenases","Polychlorinated Dibenzodioxins","Porphyrias","Uroporphyrinogen Decarboxylase"],"mesh_terms":["Polychlorinated Dibenzodioxins","Iron Deficiencies","Animals","Dioxins","Enzyme Induction","Mixed Function Oxygenases","Liver","Microsomes, Liver","Porphyrias","Uroporphyrinogen Decarboxylase","Mice"],"keywords":["Tetrachlorodibenzo-p-dioxin","Toxicity","Porphyria","Liver toxicity","Liver damage","Chemistry","Endocrinology","Internal medicine","Hepatocellular carcinoma","Pharmacology","Biology","Medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T21:38:15.854312Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}