{"doi":"10.1126/science.4001938","title":"Measles Virus Matrix Protein Synthesized in a Subacute Sclerosing Panencephalitis Cell Line","abstract":"<jats:p>Measles virus generally produces acute illness. Rarely, however, persistent infection of brain cells occurs, resulting in a chronic and fatal neurological disease, subacute sclerosing panencephalitis (SSPE). Evidence indicates that expression of the measles virus matrix protein is selectively restricted in this persistent infection, but the mechanism underlying this restriction has not been identified. Defective translation of matrix messenger RNA has been described in one SSPE cell line. This report presents evidence that in a different SSPE tissue culture cell line IP-3-Ca, the matrix protein is synthesized but fails to accumulate. A general scheme is proposed to reconcile the different levels at which restriction of matrix protein has been observed.</jats:p>","journal":"Science","year":1985,"id":590954,"datarank":2.4668606715496777,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":1.9423845373297057,"self_endowment_contribution":0.5244761342199721,"citer_contribution":1.9423845373297057,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":30,"citers_with_citation_signal":28,"citers_with_endowment":28,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1511956,"name":"Cedric S. 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Defective translation of matrix messenger RNA has been described in one SSPE cell line. This report presents evidence that in a different SSPE tissue culture cell line IP-3-Ca, the matrix protein is synthesized but fails to accumulate. A general scheme is proposed to reconcile the different levels at which restriction of matrix protein has been observed.</jats:p>","is_dataset_classified":null,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4001938","pmcid":null,"openalex_id":"https://openalex.org/W2028411163","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"NS 08952","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"NS 11920","title":null},{"funder_name":"NCI NIH HHS","grant_id":"CA13330-12","title":null}],"total_grants":3,"fwci":6.7484,"citation_percentile":0.97085496,"influential_citations":0,"citation_trend":[{"year":2021,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.4001938","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.4001938","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/4001938","host_type":"repository"}],"fields_of_study":["Virology and Viral Diseases","Virus-based gene therapy research","Syphilis Diagnosis and Treatment","Cell Line","Gene Expression Regulation","Humans","Hydrolysis","Measles virus","Molecular Weight","Mutation","Protein Processing, Post-Translational","Subacute Sclerosing Panencephalitis","Viral Matrix Proteins","Viral Proteins","Virus Replication"],"mesh_terms":["Cell Line","Gene Expression Regulation","Humans","Hydrolysis","Measles virus","Molecular Weight","Mutation","Protein Processing, Post-Translational","Subacute Sclerosing Panencephalitis","Viral Matrix Proteins","Viral Proteins","Virus Replication"],"keywords":["Subacute sclerosing panencephalitis","Measles virus","Virology","Viral matrix protein","Measles","Morbillivirus","Virus","Cell culture","Matrix (chemical analysis)","Translation (biology)","Messenger RNA","Paramyxoviridae","Biology","RNA","Slow virus","Immunology","Medicine","Viral disease","Chemistry","Gene","Genetics","Vaccination"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T13:21:33.073315Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}