{"doi":"10.1126/science.287.5460.2026","title":"A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control","abstract":"Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP6). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae, designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP6, was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression.","journal":"Science","year":2000,"id":2286,"datarank":0.8979678007926658,"base_score":5.986452005284438,"endowment":5.986452005284438,"self_citation_contribution":0.8979678007926658,"citation_network_contribution":0.0,"self_endowment_contribution":0.8979678007926658,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":397,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0418,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2000-03-17","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":28528,"name":"Alke Stahlberg","orcid":null,"position":1,"is_corresponding":false},{"id":22078,"name":"Susan R. Wente","orcid":"0000-0002-6240-548X","position":2,"is_corresponding":false},{"id":28529,"name":"John D. York","orcid":"0000-0002-3270-6345","position":3,"is_corresponding":false},{"id":28530,"name":"Audrey R. Odom John","orcid":"0000-0001-8395-8537","position":4,"is_corresponding":false},{"id":28527,"name":"Audrey R. Odom","orcid":null,"position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}