{"doi":"10.1126/science.284.5423.2174","title":"Regulation of Transcription by a Protein Methyltransferase","abstract":"<jats:p>The p160 family of coactivators, SRC-1, GRIP1/TIF2, and p/CIP, mediate transcriptional activation by nuclear hormone receptors. Coactivator-associated arginine methyltransferase 1 (CARM1), a previously unidentified protein that binds to the carboxyl-terminal region of p160 coactivators, enhanced transcriptional activation by nuclear receptors, but only when GRIP1 or SRC-1a was coexpressed. Thus, CARM1 functions as a secondary coactivator through its association with p160 coactivators. CARM1 can methylate histone H3 in vitro, and a mutation in the putative<jats:italic>S</jats:italic>-adenosylmethionine binding domain of CARM1 substantially reduced both methyltransferase and coactivator activities. Thus, coactivator-mediated methylation of proteins in the transcription machinery may contribute to transcriptional regulation.</jats:p>","journal":"Science","year":1999,"id":23126,"datarank":16.193257379268747,"base_score":7.088408778675395,"endowment":7.088408778675395,"self_citation_contribution":1.0632613168013094,"citation_network_contribution":15.129996062467438,"self_endowment_contribution":1.0632613168013094,"citer_contribution":15.129996062467438,"corpus_percentile":null,"corpus_rank":null,"citation_count":1197,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":25,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":143086,"name":"Han Ma","orcid":null,"position":1,"is_corresponding":false},{"id":143087,"name":"Heng Hong","orcid":null,"position":2,"is_corresponding":false},{"id":143088,"name":"Stephen S. 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Sequence","Animals","Cell Line","Histone Acetyltransferases","Histones","Methylation","Mice","Molecular Sequence Data","Mutation","Nuclear Receptor Coactivator 1","Nuclear Receptor Coactivator 2","Nuclear Receptor Coactivator 3","Protein-Arginine N-Methyltransferases","Receptors, Androgen","Receptors, Estrogen","Receptors, Thyroid Hormone","Recombinant Fusion Proteins","Signal Transduction","Trans-Activators","Transcription Factors","Transcriptional Activation","Transfection"],"mesh_terms":["Amino Acid Sequence","Animals","Cell Line","Histones","Methylation","Molecular Sequence Data","Mutation","Protein-Arginine N-Methyltransferases","Receptors, Androgen","Receptors, Estrogen","Receptors, Thyroid Hormone","Recombinant Fusion Proteins","Transcription Factors","Transfection","Signal Transduction","Transcriptional Activation","Trans-Activators","Mice","Histone Acetyltransferases","Nuclear Receptor Coactivator 2","Nuclear Receptor Coactivator 1","Nuclear Receptor Coactivator 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