{"doi":"10.1126/science.281.5383.1671","title":"A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation","abstract":"<jats:p>\n            The c-Jun NH\n            <jats:sub>2</jats:sub>\n            -terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.\n          </jats:p>","journal":"Science","year":1998,"id":24855,"datarank":15.936208071508608,"base_score":6.487684018484611,"endowment":6.487684018484611,"self_citation_contribution":0.9731526027726918,"citation_network_contribution":14.963055468735917,"self_endowment_contribution":0.9731526027726918,"citer_contribution":14.963055468735917,"corpus_percentile":null,"corpus_rank":null,"citation_count":656,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":1,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":147910,"name":"Julie Cavanagh","orcid":null,"position":1,"is_corresponding":false},{"id":147911,"name":"Cathy Tournier","orcid":null,"position":2,"is_corresponding":false},{"id":147912,"name":"Jun Yasuda","orcid":null,"position":3,"is_corresponding":false},{"id":119957,"name":"Roger J. Davis","orcid":null,"position":4,"is_corresponding":false},{"id":119955,"name":"Alan J. Whitmarsh","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":6.487684018484611,"endowment":6.487684018484611,"datacite_reuse_total":1,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9733513","pmcid":null,"openalex_id":"https://openalex.org/W1967218150","authors":[],"funders":[],"total_grants":0,"fwci":26.7694,"citation_percentile":0.99827198,"influential_citations":37,"citation_trend":[{"year":2012,"count":10},{"year":2013,"count":17},{"year":2014,"count":8},{"year":2015,"count":7},{"year":2016,"count":8},{"year":2017,"count":12},{"year":2018,"count":7},{"year":2019,"count":8},{"year":2020,"count":4},{"year":2021,"count":4},{"year":2022,"count":8},{"year":2023,"count":5},{"year":2024,"count":4},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.281.5383.1671","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.281.5383.1671","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9733513","host_type":"repository"},{"url":"https://escholarship.umassmed.edu/oapubs/1644","host_type":"repository"},{"url":"https://research.manchester.ac.uk/en/publications/98a9eafa-00c0-458b-8e18-49b6a5766538","host_type":"repository"},{"url":"https://www.research.manchester.ac.uk/portal/en/publications/a-mammalian-scaffold-complex-that-selectively-mediates-map-kinase-activation(98a9eafa-00c0-458b-8e18-49b6a5766538).html","host_type":"repository"}],"fields_of_study":["Melanoma and MAPK Pathways","Protein Kinase Regulation and GTPase Signaling","Signaling Pathways in Disease","Biology","Medicine","Animals","COS Cells","Calcium-Calmodulin-Dependent Protein Kinases","Carrier Proteins","Cell Line","Chlorocebus aethiops","Enzyme Activation","Interleukin-1","JNK Mitogen-Activated Protein Kinases","MAP Kinase Kinase 7","MAP Kinase Kinase Kinases","Mitogen-Activated Protein Kinase Kinases","Mitogen-Activated Protein Kinases","Molecular Sequence Data","Protein Kinases","Protein Serine-Threonine Kinases","Recombinant Fusion Proteins","Signal Transduction","Mitogen-Activated Protein Kinase Kinase Kinase 11"],"mesh_terms":["Mitogen-Activated Protein Kinase Kinase Kinase 11","Animals","Carrier Proteins","Cell Line","Chlorocebus aethiops","Enzyme Activation","Interleukin-1","Molecular Sequence Data","Protein Kinases","Recombinant Fusion Proteins","Signal Transduction","Protein Serine-Threonine Kinases","Calcium-Calmodulin-Dependent Protein Kinases","COS Cells","Mitogen-Activated Protein Kinases","Mitogen-Activated Protein Kinase Kinases","MAP Kinase Kinase Kinases","JNK Mitogen-Activated Protein Kinases","MAP Kinase Kinase 7"],"keywords":["MAP kinase kinase kinase","ASK1","MAP2K7","MAPKAPK2","MAPK7","Mitogen-activated protein kinase kinase","Mitogen-activated protein kinase","Cyclin-dependent kinase 9","c-Raf","Cell biology","MAPK14","Cyclin-dependent kinase 2","Scaffold protein","Kinase","Protein kinase R","Chemistry","Protein kinase A","Signal transduction","Biology"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.4230/lipics.dna.2020.7","title":"Implementing Non-Equilibrium Networks with Active Circuits of Duplex Catalysts","publisher":"Schloss Dagstuhl – Leibniz-Zentrum für Informatik","resource_type":"ConferencePaper"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T23:23:07.151996Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}