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The Betanova molecule constitutes a tractable model system to aid in the understanding of β-sheet formation, including β-sheet aggregation and amyloid fibril formation.</jats:p>","journal":"Science","year":1998,"id":684064,"datarank":0.8675737773494607,"base_score":5.783825182329737,"endowment":5.783825182329737,"self_citation_contribution":0.8675737773494607,"citation_network_contribution":0.0,"self_endowment_contribution":0.8675737773494607,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":324,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":478607,"name":"Marina Ramı́rez-Alvarado","orcid":"0000-0003-2325-6773","position":1,"is_corresponding":false},{"id":118776,"name":"Luis Serrano","orcid":null,"position":2,"is_corresponding":false},{"id":106697,"name":"Tanja Kortemme","orcid":"0000-0002-8494-680X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Design of a 20-Amino Acid, Three-Stranded β-Sheet Protein","abstract":"<jats:p>A 20-residue protein (named Betanova) forming a monomeric, three-stranded, antiparallel β sheet was designed using a structural backbone template and an iterative hierarchical approach. Structural and physicochemical characterization show that the β-sheet conformation is stabilized by specific tertiary interactions and that the protein exhibits a cooperative two-state folding-unfolding transition, which is a hallmark of natural proteins. The Betanova molecule constitutes a tractable model system to aid in the understanding of β-sheet formation, including β-sheet aggregation and amyloid fibril formation.</jats:p>","is_dataset_classified":null,"base_score":5.783825182329737,"endowment":5.783825182329737,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9657719","pmcid":null,"openalex_id":"https://openalex.org/W2069852256","authors":[],"funders":[],"total_grants":0,"fwci":10.8211,"citation_percentile":0.98976551,"influential_citations":0,"citation_trend":[{"year":2012,"count":8},{"year":2013,"count":6},{"year":2014,"count":4},{"year":2015,"count":9},{"year":2016,"count":8},{"year":2017,"count":8},{"year":2018,"count":5},{"year":2019,"count":4},{"year":2020,"count":1},{"year":2021,"count":6},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":3},{"year":2026,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.281.5374.253","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.281.5374.253","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9657719","host_type":"repository"}],"fields_of_study":["Protein Structure and Dynamics","Enzyme Structure and Function","Alzheimer's disease research and treatments"],"mesh_terms":["Amino Acid Sequence","Circular Dichroism","Computer Simulation","Hydrogen Bonding","Models, Molecular","Molecular Sequence Data","Protein Conformation","Protein Denaturation","Proteins","Solubility","Thermodynamics","Protein Engineering","Protein Structure, Secondary","Protein Structure, Tertiary","Protein Folding","Nuclear Magnetic Resonance, Biomolecular"],"keywords":["Antiparallel (mathematics)","Beta sheet","Monomer","Protein folding","Chemistry","Protein tertiary structure","Fibril","Biophysics","Protein structure","Structural motif","Amyloid fibril","Folding (DSP implementation)","Amino acid residue","Molecule","Peptide sequence","Crystallography","Biochemistry","Biology","Polymer","Organic chemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T13:13:09.079852Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}