{"doi":"10.1126/science.275.5304.1318","title":"Role of Transforming Growth Factor-β in Long-Term Synaptic Facilitation in\n            <i>Aplysia</i>","abstract":"<jats:p>\n            The role of transforming growth factor-β (TGF-β) in long-term synaptic facilitation was examined in isolated\n            <jats:italic>Aplysia</jats:italic>\n            ganglia. Treatment with TGF-β1 induced long-term facilitation (24 and 48 hours), but not short-term (5 to 15 minutes) or intermediate-term (2 to 4 hours) facilitation. The long-term effects of TGF-β1 were not additive with those of serotonin. Moreover, serotonin-induced facilitation was blocked by an inhibitor of TGF-β. Thus, activation of TGF-β may be part of the cascade of events underlying long-term sensitization, consistent with the hypothesis that signaling molecules that participate in development also have roles in adult neuronal plasticity.\n          </jats:p>","journal":"Science","year":1997,"id":624521,"datarank":0.7862620522589465,"base_score":5.241747015059643,"endowment":5.241747015059643,"self_citation_contribution":0.7862620522589465,"citation_network_contribution":0.0,"self_endowment_contribution":0.7862620522589465,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":188,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1614480,"name":"Shogo Endo","orcid":null,"position":1,"is_corresponding":false},{"id":500028,"name":"Leonard J. 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Moreover, serotonin-induced facilitation was blocked by an inhibitor of TGF-β. Thus, activation of TGF-β may be part of the cascade of events underlying long-term sensitization, consistent with the hypothesis that signaling molecules that participate in development also have roles in adult neuronal plasticity.\n          </jats:p>","is_dataset_classified":null,"base_score":5.241747015059643,"endowment":5.241747015059643,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9036859","pmcid":null,"openalex_id":"https://openalex.org/W1989041973","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"R01-NS-28462","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"K05 MH-00649","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01-NS-19895","title":null}],"total_grants":3,"fwci":5.0045,"citation_percentile":0.96794956,"influential_citations":15,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":10},{"year":2014,"count":8},{"year":2015,"count":6},{"year":2016,"count":7},{"year":2017,"count":4},{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":4},{"year":2021,"count":1},{"year":2022,"count":4},{"year":2023,"count":3},{"year":2024,"count":3},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.275.5304.1318","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.275.5304.1318","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9036859","host_type":"repository"}],"fields_of_study":["Neurobiology and Insect Physiology Research","Bone Tissue Engineering Materials","Planarian Biology and Electrostimulation","Biology"],"mesh_terms":["Receptor, Transforming Growth Factor-beta Type II","Animals","Aplysia","Electric Stimulation","Motor Neurons","Synaptic Transmission","Neuronal Plasticity","Neurons, Afferent","Serotonin","Synapses","Signal Transduction","Transforming Growth Factor beta","Protein Serine-Threonine Kinases","Receptors, Transforming Growth Factor beta"],"keywords":["Aplysia","Facilitation","Neural facilitation","Neuroscience","Synaptic plasticity","Transforming growth factor","Neuroplasticity","Biology","Sensitization","Serotonin","Long-term potentiation","Cell biology","Receptor","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T04:01:52.024864Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}