{"doi":"10.1126/science.2408338","title":"A New Class of Endogenous Human Retroviral Genomes","abstract":"<jats:p>\n            Human DNA contains multiple copies of a novel class of endogenous retroviral genomes. Analysis of a human recombinant DNA clone (HLM-2) containing one such proviral genome revealed that it is a mosaic of retroviral-related sequences with the organization and length of known endogenous retroviral genomes. The HLM-2 long terminal repeat hybridized with the long terminal repeat of the squirrel monkey virus, a type D retrovirus. The HLM-2\n            <jats:italic>gag</jats:italic>\n            and\n            <jats:italic>pol</jats:italic>\n            genes share extensive nucleotide sequence homology with those of the M432 retrovirus (a type A-related retrovirus), mouse mammary tumor virus (a type B retrovirus), and the avian Rous sarcoma virus (a type C retrovirus). Nucleotide sequence analysis revealed regions in the HLM-2\n            <jats:italic>pol</jats:italic>\n            gene that were as much as 70 percent identical to the mouse mammary tumor virus\n            <jats:italic>pol</jats:italic>\n            gene. A portion of the putative HLM-2\n            <jats:italic>env</jats:italic>\n            gene hybridized with the corresponding region of the M432 viral genome.\n          </jats:p>","journal":"Science","year":1985,"id":15747,"datarank":6.74649530574621,"base_score":4.5217885770490405,"endowment":4.5217885770490405,"self_citation_contribution":0.6782682865573562,"citation_network_contribution":6.068227019188853,"self_endowment_contribution":0.6782682865573562,"citer_contribution":6.068227019188853,"corpus_percentile":null,"corpus_rank":null,"citation_count":91,"citer_count":87,"citers_with_citation_signal":82,"citers_with_endowment":82,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":118946,"name":"Ing-Ming Chiu","orcid":null,"position":1,"is_corresponding":false},{"id":118948,"name":"James F. H. Wong","orcid":null,"position":2,"is_corresponding":false},{"id":118950,"name":"Stephen R. Tronick","orcid":null,"position":3,"is_corresponding":false},{"id":96585,"name":"Bruce A. Roe","orcid":null,"position":4,"is_corresponding":false},{"id":118953,"name":"Stuart A. Aaronson","orcid":null,"position":5,"is_corresponding":false},{"id":118955,"name":"Jeffrey Schlom","orcid":null,"position":6,"is_corresponding":false},{"id":118944,"name":"Robert Callahan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.5217885770490405,"endowment":4.5217885770490405,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"2408338","pmcid":null,"openalex_id":"https://openalex.org/W2033422722","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"GM30400","title":null}],"total_grants":1,"fwci":23.9096,"citation_percentile":0.99641088,"influential_citations":6,"citation_trend":[{"year":2012,"count":1},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2018,"count":1},{"year":2020,"count":1},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.2408338","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.2408338","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/2408338","host_type":"repository"}],"fields_of_study":["Chromosomal and Genetic Variations","Plant Virus Research Studies","T-cell and Retrovirus Studies","Biology","Medicine"],"mesh_terms":["Amino Acid Sequence","Antigens, Viral","Base Sequence","Cloning, Molecular","DNA Restriction Enzymes","Genes, Viral","Humans","Retroviridae","RNA-Directed DNA Polymerase","Viral Proteins","Gene Products, gag"],"keywords":["Retrovirus","Biology","Rous sarcoma virus","Long terminal repeat","Genome","Endogenous retrovirus","Gene","Virology","Provirus","Genetics","Mouse mammary tumor virus","Group-specific antigen","Virus"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T18:49:53.291477Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}