{"doi":"10.1126/science.224454","title":"Trigeminal Ganglion Infection by Thymidine Kinase-Negative Mutants of Herpes Simplex Virus","abstract":"<jats:p>The incidence of trigeminal ganglion infection after corneal inoculation of guinea pigs with thymidine kinase-negative mutants of herpes simplex virus was markedly reduced compared to infection after inoculation of thymidine kinase-positive virus. Thymidine kinase-negative herpes simplex virus replicated well in ocular tissues in which dividing or potentially dividing cells were present, but not in trigeminal ganglion infection of nondividing neurons. Thymidine kinase-positive virus, however, replicated well in ocular tissues as well as in trigeminal ganglion. These results suggest that thymidine kinase expression of herpes simplex virus may be important in infections of sensory ganglia.</jats:p>","journal":"Science","year":1979,"id":15897,"datarank":14.154620806469664,"base_score":5.1647859739235145,"endowment":5.1647859739235145,"self_citation_contribution":0.7747178960885273,"citation_network_contribution":13.379902910381137,"self_endowment_contribution":0.7747178960885273,"citer_contribution":13.379902910381137,"corpus_percentile":null,"corpus_rank":null,"citation_count":174,"citer_count":168,"citers_with_citation_signal":157,"citers_with_endowment":157,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":110837,"name":"Richard L. Miller","orcid":null,"position":1,"is_corresponding":false},{"id":119456,"name":"Fred Rapp","orcid":null,"position":2,"is_corresponding":false},{"id":119455,"name":"Richard B. Tenser","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.1647859739235145,"endowment":5.1647859739235145,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"224454","pmcid":null,"openalex_id":"https://openalex.org/W2078302353","authors":[],"funders":[],"total_grants":0,"fwci":9.1355,"citation_percentile":0.98328448,"influential_citations":4,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":3},{"year":2014,"count":2},{"year":2016,"count":1},{"year":2019,"count":2},{"year":2021,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.224454","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.224454","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/224454","host_type":"repository"}],"fields_of_study":["Herpesvirus Infections and Treatments","Acne and Rosacea Treatments and Effects","Peripheral Neuropathies and Disorders","Biology","Medicine","Animals","Corneal Diseases","Guinea Pigs","Herpes Simplex","Peripheral Nervous System Diseases","Simplexvirus","Thymidine Kinase","Trigeminal Ganglion","Trigeminal Nerve"],"mesh_terms":["Animals","Corneal Diseases","Guinea Pigs","Herpes Simplex","Peripheral Nervous System Diseases","Trigeminal Ganglion","Thymidine Kinase","Trigeminal Nerve","Simplexvirus"],"keywords":["Thymidine kinase","Trigeminal ganglion","Herpes simplex virus","Thymidine","Ganglion","Virology","Biology","Virus","Kinase","Cell biology","Sensory system","Anatomy","Neuroscience","Biochemistry","DNA"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T19:29:54.310235Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}