{"doi":"10.1126/science.148.3678.1728","title":"Complement: Increased Efficiency of the Second Component after Treatment with Iodoacetamide","abstract":"\n The apparent activity of the second component of human complement was enhanced by treatment of the purified protein with iodoacetamide. By contrast, treatment with iodoacetic acid or\n p\n -chloromercuribenzoate led to inactivation. Treatment with iodoacetamide prevented the effect of\n p\n -chloromercuribenzoate and vice versa. Enhanced activity was partly due to increased stability of the otherwise labile intermediate complex consisting of erythrocytes, antibody, and the first, second, and fourth components of complement.\n ","journal":"Science","year":1965,"id":35548,"datarank":0.3960504601856165,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.12728653980140822,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.12728653980140822,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":3,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":42.5,"fair_percentile":21.459982409850483,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":181833,"name":"Hans J. Müller-Eberhard","orcid":null,"position":1,"is_corresponding":false},{"id":181832,"name":"Margaret J. Polley","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17819427","pmcid":null,"openalex_id":"https://openalex.org/W1999902330","authors":[],"funders":[],"total_grants":0,"fwci":2.1989,"citation_percentile":0.87175117,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.148.3678.1728","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.148.3678.1728","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17819427","host_type":"repository"}],"fields_of_study":["Complement system in diseases","Blood groups and transfusion","Hemoglobin structure and function","Medicine","Chemistry","Biology"],"mesh_terms":[],"keywords":["Iodoacetamide","Iodoacetic acid","Complement (music)","Chemistry","Biochemistry","Antibody","Component (thermodynamics)","Biophysics","Immunology","Enzyme","Biology","Cysteine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-10T04:41:51.631295Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":100.0,"fair_a":70.0,"fair_i":0.0,"fair_r":0.0,"fair_zscore":-0.2453,"fair_rationale":{"fair_score":42.5,"has_llm":false,"dimensions":{"F":{"name":"Findable","score":100.0,"criteria":[{"key":"f_has_doi","label":"Has a persistent DOI","kind":"deterministic","weight":1.0,"fraction":1.0,"signal":"DOI present","rationale":null},{"key":"f_repository_presence","label":"Indexed in repositories / literature DBs","kind":"deterministic","weight":1.0,"fraction":1.0,"signal":"datacite=0, pmcid=False, pmid=True","rationale":null},{"key":"f_persistent_ids","label":"Resolvable scholarly identifiers (OpenAlex)","kind":"deterministic","weight":0.5,"fraction":1.0,"signal":"OpenAlex id present","rationale":null}]},"A":{"name":"Accessible","score":70.0,"criteria":[{"key":"a_open_access","label":"Open Access / files deposited","kind":"deterministic","weight":1.5,"fraction":0.5,"signal":"files/OA location present but not flagged OA","rationale":null},{"key":"a_retrievable","label":"Free full text retrievable","kind":"deterministic","weight":1.0,"fraction":1.0,"signal":"3 OA location(s)","rationale":null}]},"I":{"name":"Interoperable","score":0.0,"criteria":[{"key":"i_linked_data","label":"Linked datasets / DataCite relations","kind":"deterministic","weight":1.0,"fraction":0.0,"signal":"linked_datasets=0, datacite=0","rationale":null},{"key":"i_standard_ids","label":"References data via standard accessions","kind":"deterministic","weight":1.0,"fraction":0.0,"signal":"accessions=0, trials=0","rationale":null}]},"R":{"name":"Reusable","score":0.0,"criteria":[{"key":"r_license","label":"Clear, open reuse license","kind":"deterministic","weight":1.5,"fraction":0.0,"signal":"no license","rationale":null},{"key":"r_downloads","label":"Demonstrated reuse (downloads)","kind":"deterministic","weight":0.5,"fraction":0.0,"signal":"downloads=0","rationale":null},{"key":"r_version","label":"Versioned / maintained","kind":"deterministic","weight":0.5,"fraction":0.0,"signal":"no version chain","rationale":null},{"key":"r_dataset","label":"Classified as a data resource","kind":"deterministic","weight":0.5,"fraction":0.0,"signal":"not a dataset","rationale":null}]}},"suggestions":["Attach a clear, open reuse license (e.g. CC-BY or CC0).","Link the underlying datasets via DOIs / DataCite relations.","Reference data using standard accessions (e.g. GEO, PDB, ClinicalTrials.gov).","Maintain explicit versioning for the dataset.","Make the paper/data Open Access or deposit the files in an open repository."],"model":null,"agent_version":"fair_agent_v1","fulltext_source":"abstract_only"},"fair_model":null,"fair_agent_version":"fair_agent_v1","fair_fulltext_source":"abstract_only","fair_has_llm":false,"fair_computed_at":"2026-06-10T11:52:21.267278Z","clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}