{"doi":"10.1126/science.1239278","title":"Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds","abstract":"<jats:title>Promoting Pluripotency</jats:title>\n                  <jats:p>\n                    A specialized mammalian cell can be set back to the pluripotent state either by transfer of the somatic cell nucleus into an oocyte or by delivery of exogenous pluripotency-associated transcription factors.\n                    <jats:bold>\n                      Hou\n                      <jats:italic>et al.</jats:italic>\n                    </jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6146\" page=\"651\" related-article-type=\"in-this-issue\" vol=\"341\" xlink:href=\"10.1126/science.1239278\">651</jats:related-article>\n                    , published online 18 July) developed an approach to induce pluripotency in somatic cells using a cocktail of small molecules. The ability to generate such chemically induced pluripotent stem cells may provide an alternate route for therapeutic cloning and for drug development in regenerative medicine.\n                  </jats:p>","journal":"Science","year":2013,"id":17647,"datarank":11.532841052639263,"base_score":7.234898420314831,"endowment":7.234898420314831,"self_citation_contribution":1.0852347630472248,"citation_network_contribution":10.447606289592038,"self_endowment_contribution":1.0852347630472248,"citer_contribution":10.447606289592038,"corpus_percentile":null,"corpus_rank":null,"citation_count":1386,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":25,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":125563,"name":"Yanqin Li","orcid":null,"position":1,"is_corresponding":false},{"id":51844,"name":"Xu Zhang","orcid":null,"position":2,"is_corresponding":false},{"id":63831,"name":"Chun Liu","orcid":"0000-0001-8740-5673","position":3,"is_corresponding":false},{"id":125564,"name":"Jingyang Guan","orcid":null,"position":4,"is_corresponding":false},{"id":125565,"name":"Honggang Li","orcid":null,"position":5,"is_corresponding":false},{"id":125566,"name":"Ting Zhao","orcid":null,"position":6,"is_corresponding":false},{"id":125567,"name":"Junqing Ye","orcid":null,"position":7,"is_corresponding":false},{"id":123471,"name":"Weifeng Yang","orcid":null,"position":8,"is_corresponding":false},{"id":125568,"name":"Kang Liu","orcid":null,"position":9,"is_corresponding":false},{"id":125569,"name":"Jian Ge","orcid":null,"position":10,"is_corresponding":false},{"id":35938,"name":"Jun Xu","orcid":"0000-0002-7140-7823","position":11,"is_corresponding":false},{"id":71106,"name":"Qiang Zhang","orcid":"0000-0001-6662-1668","position":12,"is_corresponding":false},{"id":115363,"name":"Yang Zhao","orcid":null,"position":13,"is_corresponding":false},{"id":123476,"name":"Hongkui Deng","orcid":null,"position":14,"is_corresponding":false},{"id":125562,"name":"Pingping Hou","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":7.234898420314831,"endowment":7.234898420314831,"datacite_reuse_total":25,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23868920","pmcid":null,"openalex_id":"https://openalex.org/W2101569447","authors":[],"funders":[],"total_grants":0,"fwci":84.7997,"citation_percentile":0.99973938,"influential_citations":54,"citation_trend":[{"year":2013,"count":58},{"year":2014,"count":183},{"year":2015,"count":165},{"year":2016,"count":161},{"year":2017,"count":111},{"year":2018,"count":112},{"year":2019,"count":81},{"year":2020,"count":82},{"year":2021,"count":89},{"year":2022,"count":75},{"year":2023,"count":82},{"year":2024,"count":83},{"year":2025,"count":72},{"year":2026,"count":32}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.1239278","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.1239278","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23868920","host_type":"repository"}],"fields_of_study":["Pluripotent Stem Cells Research","CRISPR and Genetic Engineering","3D Printing in Biomedical Research","Biology","Medicine","Animals","Cadherins","Cell Engineering","Cellular Reprogramming","Epithelial-Mesenchymal Transition","Fibroblasts","Gene Expression Profiling","Green Fluorescent Proteins","Induced Pluripotent Stem Cells","Mice","Mice, Inbred C57BL","Mice, Inbred ICR","Octamer Transcription Factor-3","Promoter Regions, Genetic","Small Molecule Libraries"],"mesh_terms":["Animals","Fibroblasts","Mice, Inbred C57BL","Mice, Inbred ICR","Promoter Regions, Genetic","Cadherins","Gene Expression Profiling","Green Fluorescent Proteins","Octamer Transcription Factor-3","Mice","Small Molecule Libraries","Induced Pluripotent Stem Cells","Epithelial-Mesenchymal Transition","Cell Engineering","Cellular Reprogramming"],"keywords":["Reprogramming","Induced pluripotent stem cell","Somatic cell","Embryonic stem cell","Biology","Stem cell","Cell biology","Regenerative medicine","Germline","Cell 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