{"doi":"10.1126/science.1194597","title":"Lineage Relationship Analysis of RORγt\n                    <sup>+</sup>\n                    Innate Lymphoid Cells","abstract":"<jats:title>Innate Innit?</jats:title>\n                  <jats:p>\n                    Innate lymphocytes (ILCs) are a recently described population of immune cells that produce cytokines like those associated with T helper cells, but lack the recombined antigen receptors characteristic of T cells. Again, like some T helper cell lineages, a proportion of ILCs express the transcription factor RORγt. These include lymphoid tissue inducer (LTi) cells required for fetal lymphoid tissue organogenesis and a population of natural killer (NK)–like cells that function in gut immune responses.\n                    <jats:bold>\n                      Sawa\n                      <jats:italic>et al.</jats:italic>\n                    </jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"665\" related-article-type=\"in-this-issue\" vol=\"330\" xlink:href=\"10.1126/science.1194597\">665</jats:related-article>\n                    ; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6004\" page=\"594\" related-article-type=\"in-this-issue\" vol=\"330\" xlink:href=\"10.1126/science.1198298\">Veldhoen and Withers</jats:related-article>\n                    </jats:bold>\n                    ) wondered whether the RORγt-expressing ILCs all develop from the same progenitor population. Indeed, they found a fetal liver progenitor that gave rise to several phenotypically distinct populations. However, the LTi cells were not progenitors for the NK-like cells. It seems the trajectory of different ILC populations is developmentally regulated, and postnatally ILCs are favored that play a role in intestinal defense before the gut is fully colonized by intestinal microbiota.\n                  </jats:p>","journal":"Science","year":2010,"id":632247,"datarank":0.931590011553698,"base_score":6.210600077024653,"endowment":6.210600077024653,"self_citation_contribution":0.931590011553698,"citation_network_contribution":0.0,"self_endowment_contribution":0.931590011553698,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":497,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1638775,"name":"Marie Cherrier","orcid":null,"position":1,"is_corresponding":false},{"id":1298932,"name":"Matthias Lochner","orcid":"0000-0002-7979-5613","position":2,"is_corresponding":false},{"id":1512327,"name":"Naoko Satoh-Takayama","orcid":null,"position":3,"is_corresponding":false},{"id":1638776,"name":"Hans Jörg Fehling","orcid":null,"position":4,"is_corresponding":false},{"id":720013,"name":"Francina Langa","orcid":null,"position":5,"is_corresponding":false},{"id":263550,"name":"James P. Di Santo","orcid":"0000-0002-7146-1862","position":6,"is_corresponding":false},{"id":718221,"name":"Gérard Eberl","orcid":"0000-0002-1119-5638","position":7,"is_corresponding":false},{"id":1374494,"name":"Shinichiro Sawa","orcid":"0000-0002-8850-446X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Lineage Relationship Analysis of RORγt\n                    <sup>+</sup>\n                    Innate Lymphoid Cells","abstract":"<jats:title>Innate Innit?</jats:title>\n                  <jats:p>\n                    Innate lymphocytes (ILCs) are a recently described population of immune cells that produce cytokines like those associated with T helper cells, but lack the recombined antigen receptors characteristic of T cells. Again, like some T helper cell lineages, a proportion of ILCs express the transcription factor RORγt. These include lymphoid tissue inducer (LTi) cells required for fetal lymphoid tissue organogenesis and a population of natural killer (NK)–like cells that function in gut immune responses.\n                    <jats:bold>\n                      Sawa\n                      <jats:italic>et al.</jats:italic>\n                    </jats:bold>\n                    (p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"665\" related-article-type=\"in-this-issue\" vol=\"330\" xlink:href=\"10.1126/science.1194597\">665</jats:related-article>\n                    ; see the Perspective by\n                    <jats:bold>\n                      <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6004\" page=\"594\" related-article-type=\"in-this-issue\" vol=\"330\" xlink:href=\"10.1126/science.1198298\">Veldhoen and Withers</jats:related-article>\n                    </jats:bold>\n                    ) wondered whether the RORγt-expressing ILCs all develop from the same progenitor population. Indeed, they found a fetal liver progenitor that gave rise to several phenotypically distinct populations. However, the LTi cells were not progenitors for the NK-like cells. It seems the trajectory of different ILC populations is developmentally regulated, and postnatally ILCs are favored that play a role in intestinal defense before the gut is fully colonized by intestinal microbiota.\n                  </jats:p>","is_dataset_classified":null,"base_score":6.210600077024653,"endowment":6.210600077024653,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20929731","pmcid":null,"openalex_id":"https://openalex.org/W1979408872","authors":[],"funders":[],"total_grants":0,"fwci":14.0293,"citation_percentile":0.99353523,"influential_citations":0,"citation_trend":[{"year":2012,"count":43},{"year":2013,"count":49},{"year":2014,"count":37},{"year":2015,"count":44},{"year":2016,"count":40},{"year":2017,"count":37},{"year":2018,"count":25},{"year":2019,"count":37},{"year":2020,"count":34},{"year":2021,"count":20},{"year":2022,"count":20},{"year":2023,"count":31},{"year":2024,"count":18},{"year":2025,"count":13},{"year":2026,"count":11}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.1194597","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.1194597","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20929731","host_type":"repository"},{"url":"https://pasteur.hal.science/pasteur-01402753","host_type":"repository"}],"fields_of_study":["IL-33, ST2, and ILC Pathways","Eosinophilic Esophagitis","Immune Cell Function and Interaction"],"mesh_terms":["Animals","Cell Differentiation","Fetus","Homeostasis","Intestinal Mucosa","Intestine, Small","Liver","Lymphocytes","Lymphoid Tissue","Mice, Transgenic","Symbiosis","Lymphocyte Subsets","T-Lymphocyte Subsets","Bacterial Physiological Phenomena","Immunity, Mucosal","Cell Lineage","Adoptive Transfer","Lymphopoiesis","Mice","Receptors, CCR6","Lymphoid Progenitor Cells","Adaptive Immunity","Nuclear Receptor Subfamily 1, Group F, Member 3"],"keywords":["Innate lymphoid cell","RAR-related orphan receptor gamma","Biology","Orphan receptor","Proinflammatory cytokine","Cell biology","Thymic stromal lymphopoietin","Nuclear receptor","Immunology","Stromal cell","Cytokine","Inflammation","FOXP3","Cancer research","Innate immune system","Immune system","Transcription factor","Genetics"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T09:18:25.230204Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}