{"doi":"10.1126/science.1188224","title":"Development of the Hippocampal Cognitive Map in Preweanling Rats","abstract":"<jats:title>The Space in Your Head</jats:title>\n          <jats:p>\n            Space, and events associated with places and spaces, are represented in the brain by a circuitry made of place cells, head direction cells, grid cells, and border cells. These cell types form a collective dynamic representation of our position as we move through the environment. How this representation is formed has remained a mystery. Is it acquired, or are we born with the ability to represent external space (see the Perspective by\n            <jats:bold>\n              <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"5985\" page=\"1487\" related-article-type=\"in-this-issue\" vol=\"328\" xlink:href=\"10.1126/science.1191527\">\n                <jats:bold>Palmer and Lynch</jats:bold>\n              </jats:related-article>\n            </jats:bold>\n            )?\n            <jats:bold>\n              Langston\n              <jats:italic>et al.</jats:italic>\n            </jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"1576\" related-article-type=\"in-this-issue\" vol=\"328\" xlink:href=\"10.1126/science.1188210\">1576</jats:related-article>\n            ) and\n            <jats:bold>\n              Wills\n              <jats:italic>et al.</jats:italic>\n            </jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"1573\" related-article-type=\"in-this-issue\" vol=\"328\" xlink:href=\"10.1126/science.1188224\">1573</jats:related-article>\n            ) investigated the early development of spatial activity in the hippocampal formation and the entorhinal cortex of rat pups when they first began to explore their environment. Rudiments of place cells, head direction cells, and grid cells already existed when the pups made their first movements out of the nest. A neural representation of external space at this early time points to strong innate components for perception of space. These findings provide experimental support for Kant's 200-year-old concept of space as an a priori faculty of the mind.\n          </jats:p>","journal":"Science","year":2010,"id":32298,"datarank":11.965861663130209,"base_score":6.452048954437226,"endowment":6.452048954437226,"self_citation_contribution":0.967807343165584,"citation_network_contribution":10.998054319964625,"self_endowment_contribution":0.967807343165584,"citer_contribution":10.998054319964625,"corpus_percentile":null,"corpus_rank":null,"citation_count":633,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":171269,"name":"Francesca Cacucci","orcid":null,"position":1,"is_corresponding":false},{"id":98469,"name":"Neil Burgess","orcid":"0000-0003-0646-6584","position":2,"is_corresponding":false},{"id":171270,"name":"John O'Keefe","orcid":null,"position":3,"is_corresponding":false},{"id":171268,"name":"Tom J. Wills","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":6.452048954437226,"endowment":6.452048954437226,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20558720","pmcid":"PMC3543985","openalex_id":"https://openalex.org/W1968023011","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"082507","title":null},{"funder_name":"Medical Research Council","grant_id":"G0501672","title":null},{"funder_name":"European Commission","grant_id":"200873","title":"Space coding in hippocampo-entorhinal neuronal assemblies"}],"total_grants":3,"fwci":20.6245,"citation_percentile":0.99710382,"influential_citations":30,"citation_trend":[{"year":2012,"count":42},{"year":2013,"count":40},{"year":2014,"count":62},{"year":2015,"count":49},{"year":2016,"count":28},{"year":2017,"count":45},{"year":2018,"count":37},{"year":2019,"count":37},{"year":2020,"count":61},{"year":2021,"count":33},{"year":2022,"count":27},{"year":2023,"count":23},{"year":2024,"count":67},{"year":2025,"count":27},{"year":2026,"count":12}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3543985","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc3543985?pdf=render","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3543985","host_type":"repository"},{"url":"https://www.science.org/doi/pdf/10.1126/science.1188224","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.1188224","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20558720","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.220.6059","host_type":""},{"url":"http://discovery.ucl.ac.uk/150034/","host_type":"repository"},{"url":"http://dx.doi.org/10.1126/science.1188224","host_type":""},{"url":"https://dx.doi.org/10.1126/science.1188224","host_type":""}],"fields_of_study":["Memory and Neural Mechanisms","Sleep and Wakefulness Research","Neuroscience and Neuropharmacology Research","Psychology","Medicine","Biology","Action Potentials","Aging","Animals","Animals, Suckling","Brain Mapping","CA1 Region, Hippocampal","Cognition","Electrodes, Implanted","Entorhinal Cortex","Exploratory Behavior","Male","Neurons","Orientation","Pyramidal Cells","Rats","Space Perception","Spatial Behavior","Theta Rhythm"],"mesh_terms":["Action Potentials","Aging","Animals","Animals, Suckling","Brain Mapping","Cognition","Electrodes, Implanted","Exploratory Behavior","Male","Neurons","Orientation","Space Perception","Spatial Behavior","Theta Rhythm","Pyramidal Cells","Entorhinal Cortex","Rats","CA1 Region, Hippocampal"],"keywords":["Hippocampal formation","Place cell","Cognitive map","Neuroscience","Space (punctuation)","Grid cell","Cognition","Psychology","Hippocampus","Cognitive psychology","Grid","Biology","Communication","Computer science","Geography","Male","Neurons","Aging","Brain Mapping","Pyramidal Cells","Action Potentials","Spatial Behavior","Animals, Suckling","Electrodes, Implanted","Rats","Orientation","Space Perception","Exploratory Behavior","Animals","Entorhinal Cortex","Theta Rhythm","CA1 Region, Hippocampal"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Sustainable cities and communities"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T11:18:59.390774Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}