{"doi":"10.1126/science.1181958","title":"A Transient Niche Regulates the Specification of\n            <i>Drosophila</i>\n            Intestinal Stem Cells","abstract":"<jats:title>Niche Metamorphosis</jats:title>\n          <jats:p>\n            The gut epithelium is continually renewed by cells generated from intestinal stem cells. In the fruit fly\n            <jats:italic>Drosophila</jats:italic>\n            , cells of the adult gut are derived from cells set aside before metamorphosis.\n            <jats:bold>\n              Mathur\n              <jats:italic>et al.</jats:italic>\n            </jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"210\" related-article-type=\"in-this-issue\" vol=\"327\" xlink:href=\"10.1126/science.1181958\">210</jats:related-article>\n            ) now show that an early asymmetric cell division in larval stages establishes a niche that encloses a proliferating group of undifferentiated stem cells. At metamorphosis, the niche breaks down and the stem cells are freed. Most of them differentiate into adult gut progenitors, but a minority takes on the task of establishing a new, adult, stem cell niche with more liberal operating rules.\n          </jats:p>","journal":"Science","year":2010,"id":645610,"datarank":0.7846662925281881,"base_score":5.231108616854587,"endowment":5.231108616854587,"self_citation_contribution":0.7846662925281881,"citation_network_contribution":0.0,"self_endowment_contribution":0.7846662925281881,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":186,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1681153,"name":"Alyssa Bost","orcid":null,"position":1,"is_corresponding":false},{"id":1016580,"name":"Ian Driver","orcid":"0000-0002-2674-5532","position":2,"is_corresponding":false},{"id":1681154,"name":"Benjamin Ohlstein","orcid":null,"position":3,"is_corresponding":false},{"id":1681152,"name":"Divya Mathur","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Transient Niche Regulates the Specification of\n            <i>Drosophila</i>\n            Intestinal Stem Cells","abstract":"<jats:title>Niche Metamorphosis</jats:title>\n          <jats:p>\n            The gut epithelium is continually renewed by cells generated from intestinal stem cells. In the fruit fly\n            <jats:italic>Drosophila</jats:italic>\n            , cells of the adult gut are derived from cells set aside before metamorphosis.\n            <jats:bold>\n              Mathur\n              <jats:italic>et al.</jats:italic>\n            </jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"210\" related-article-type=\"in-this-issue\" vol=\"327\" xlink:href=\"10.1126/science.1181958\">210</jats:related-article>\n            ) now show that an early asymmetric cell division in larval stages establishes a niche that encloses a proliferating group of undifferentiated stem cells. At metamorphosis, the niche breaks down and the stem cells are freed. Most of them differentiate into adult gut progenitors, but a minority takes on the task of establishing a new, adult, stem cell niche with more liberal operating rules.\n          </jats:p>","is_dataset_classified":null,"base_score":5.231108616854587,"endowment":5.231108616854587,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20056890","pmcid":"PMC2857772","openalex_id":"https://openalex.org/W1975473156","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK082456","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM007088","title":null}],"total_grants":2,"fwci":7.6638,"citation_percentile":0.98130421,"influential_citations":0,"citation_trend":[{"year":2012,"count":13},{"year":2013,"count":18},{"year":2014,"count":11},{"year":2015,"count":15},{"year":2016,"count":7},{"year":2017,"count":7},{"year":2018,"count":13},{"year":2019,"count":9},{"year":2020,"count":10},{"year":2021,"count":4},{"year":2022,"count":10},{"year":2023,"count":8},{"year":2024,"count":10},{"year":2025,"count":7},{"year":2026,"count":3}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2857772","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2857772","host_type":"repository"},{"url":"https://www.science.org/doi/pdf/10.1126/science.1181958","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.1181958","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20056890","host_type":"repository"}],"fields_of_study":["Invertebrate Immune Response Mechanisms","Neurobiology and Insect Physiology Research","Developmental Biology and Gene Regulation"],"mesh_terms":["Animals","Cell Differentiation","Drosophila","Epithelial Cells","Intestines","Larva","Metamorphosis, Biological","Signal Transduction","Cell Lineage","Enterocytes","Drosophila Proteins","Organogenesis","Cell Proliferation","Receptors, Notch","Adult Stem Cells","Stem Cell Niche"],"keywords":["Niche","Metamorphosis","Stem cell","Biology","Cell biology","Progenitor cell","Adult stem cell","Drosophila (subgenus)","Stem cell niche","Larva","Cellular differentiation","Ecology","Genetics","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T09:31:51.567929Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}