{"doi":"10.1126/science.1180278","title":"Targeted 3′ Processing of Antisense Transcripts Triggers\n            <i>Arabidopsis FLC</i>\n            Chromatin Silencing","abstract":"Noncoding RNA is emerging as an important regulator of gene expression in many organisms. We are characterizing RNA-mediated chromatin silencing of the Arabidopsis major floral repressor gene, FLC. Through suppressor mutagenesis, we identify a requirement for CstF64 and CstF77, two conserved RNA 3'-end-processing factors, in FLC silencing. However, FLC sense transcript 3' processing is not affected in the mutants. Instead, CstF64 and CstF77 are required for 3' processing of FLC antisense transcripts. A specific RNA-binding protein directs their activity to a proximal antisense polyadenylation site. This targeted processing triggers localized histone demethylase activity and results in reduced FLC sense transcription. Targeted 3' processing of antisense transcripts may be a common mechanism triggering transcriptional silencing of the corresponding sense gene.","journal":"Science","year":2010,"id":2952,"datarank":0.927312736007495,"base_score":6.182084906716632,"endowment":6.182084906716632,"self_citation_contribution":0.927312736007495,"citation_network_contribution":0.0,"self_endowment_contribution":0.927312736007495,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":483,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0485,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2010-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":32748,"name":"Sebastian Marquardt","orcid":"0000-0003-1709-2717","position":1,"is_corresponding":false},{"id":32749,"name":"Clare Lister","orcid":null,"position":2,"is_corresponding":false},{"id":32750,"name":"Szymon Swiezewski","orcid":null,"position":3,"is_corresponding":false},{"id":32751,"name":"Caroline Dean","orcid":"0000-0002-6555-3525","position":4,"is_corresponding":false},{"id":32752,"name":"Szymon Świeżewski","orcid":"0000-0002-2007-2779","position":5,"is_corresponding":false},{"id":32747,"name":"Fuquan Liu","orcid":"0000-0001-8764-6370","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}