{"doi":"10.1126/science.1175371","title":"Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions","abstract":"Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression. Technological limitations have so far prevented a global analysis of lysine acetylation's cellular roles. We used high-resolution mass spectrometry to identify 3600 lysine acetylation sites on 1750 proteins and quantified acetylation changes in response to the deacetylase inhibitors suberoylanilide hydroxamic acid and MS-275. Lysine acetylation preferentially targets large macromolecular complexes involved in diverse cellular processes, such as chromatin remodeling, cell cycle, splicing, nuclear transport, and actin nucleation. Acetylation impaired phosphorylation-dependent interactions of 14-3-3 and regulated the yeast cyclin-dependent kinase Cdc28. Our data demonstrate that the regulatory scope of lysine acetylation is broad and comparable with that of other major posttranslational modifications.","journal":"Science","year":2009,"id":4803,"datarank":1.2448928860345914,"base_score":8.299285906897275,"endowment":8.299285906897275,"self_citation_contribution":1.2448928860345914,"citation_network_contribution":0.0,"self_endowment_contribution":1.2448928860345914,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4020,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.044,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2009-08-14","fair_score":67.5,"fair_percentile":94.7,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":50218,"name":"Chanchal Kumar","orcid":null,"position":1,"is_corresponding":false},{"id":50219,"name":"Florian Gnad","orcid":"0000-0002-2287-2251","position":2,"is_corresponding":false},{"id":50220,"name":"Michael L. 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