{"doi":"10.1126/science.1171347","title":"Transcriptional Regulatory Circuits: Predicting Numbers from Alphabets","abstract":"Transcriptional regulatory circuits govern how cis and trans factors transform signals into messenger RNA (mRNA) expression levels. With advances in quantitative and high-throughput technologies that allow measurement of gene expression state in different conditions, data that can be used to build and test models of transcriptional regulation is being generated at a rapid pace. Here, we review experimental and computational methods used to derive detailed quantitative circuit models on a small scale and cruder, genome-wide models on a large scale. We discuss the potential of combining small- and large-scale approaches to understand the working and wiring of transcriptional regulatory circuits.","journal":"Science","year":2009,"id":9962,"datarank":1.5016361691755633,"base_score":4.969813299576001,"endowment":4.969813299576001,"self_citation_contribution":0.7454719949364003,"citation_network_contribution":0.756164174239163,"self_endowment_contribution":0.7454719949364003,"citer_contribution":0.756164174239163,"corpus_percentile":null,"corpus_rank":null,"citation_count":143,"citer_count":34,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0717,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2009-07-24","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":16659,"name":"Tal Shay","orcid":"0000-0003-0755-1350","position":1,"is_corresponding":false},{"id":22080,"name":"Erin K. O’Shea","orcid":"0000-0002-2649-1018","position":2,"is_corresponding":false},{"id":29633,"name":"Prisca Liberali","orcid":"0000-0003-0695-6081","position":3,"is_corresponding":false},{"id":62636,"name":"Harold D. Kim","orcid":"0000-0003-0878-2169","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}