{"doi":"10.1126/science.1156093","title":"Regulation of the Cellular Heat Shock Response in\n                    <i>Caenorhabditis elegans</i>\n                    by Thermosensory Neurons","abstract":"<jats:p>\n                    Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we show that within the metazoan\n                    <jats:italic>Caenorhabditis elegans</jats:italic>\n                    , the heat shock response of somatic cells is not cell-autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperature and regulates temperature-dependent behavior. We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change.\n                  </jats:p>","journal":"Science","year":2008,"id":657706,"datarank":10.530248765138282,"base_score":5.924255797414532,"endowment":5.924255797414532,"self_citation_contribution":0.88863836961218,"citation_network_contribution":9.641610395526103,"self_endowment_contribution":0.88863836961218,"citer_contribution":9.641610395526103,"corpus_percentile":null,"corpus_rank":null,"citation_count":373,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1716901,"name":"Tyler Cornelius","orcid":null,"position":1,"is_corresponding":false},{"id":141529,"name":"Richard I. Morimoto","orcid":null,"position":2,"is_corresponding":false},{"id":328425,"name":"Veena Prahlad","orcid":"0000-0002-0413-6074","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons.","abstract":"Temperature pervasively affects all cellular processes. In response to a rapid increase in temperature, all cells undergo a heat shock response, an ancient and highly conserved program of stress-inducible gene expression, to reestablish cellular homeostasis. In isolated cells, the heat shock response is initiated by the presence of misfolded proteins and therefore thought to be cell-autonomous. In contrast, we show that within the metazoan Caenorhabditis elegans, the heat shock response of somatic cells is not cell-autonomous but rather depends on the thermosensory neuron, AFD, which senses ambient temperature and regulates temperature-dependent behavior. We propose a model whereby this loss of cell autonomy serves to integrate behavioral, metabolic, and stress-related responses to establish an organismal response to environmental change.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18467592","pmcid":"PMC3429343","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"R01 AG026647","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R37 GM038109","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM038109","title":null}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":null,"oa_locations":[],"fields_of_study":[],"mesh_terms":["Neurons, Afferent","Animals","Caenorhabditis elegans","Heat-Shock Proteins","Caenorhabditis elegans Proteins","Transcription Factors","Pheromones","Protein Folding","Heat-Shock Response","Mutation","Genes, Helminth","Models, Neurological","Thermosensing"],"keywords":[],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.14344481.v1","title":"Additional file 1 of Effect of policosanol from insect wax on amyloid β-peptide-induced toxicity in a transgenic Caenorhabditis elegans model of Alzheimer’s disease","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14344481","title":"Additional file 1 of Effect of policosanol from insect wax on amyloid β-peptide-induced toxicity in a transgenic Caenorhabditis elegans model of Alzheimer’s disease","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T02:05:35.900150Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}