{"doi":"10.1126/science.1143422","title":"Parallels Between Cytokinesis and Retroviral Budding: A Role for the ESCRT Machinery","abstract":"<jats:p>During cytokinesis, as dividing animal cells pull apart into two daughter cells, the final stage, termed abscission, requires breakage of the midbody, a thin membranous stalk connecting the daughter cells. This membrane fission event topologically resembles the budding of viruses, such as HIV-1, from infected cells. We found that two proteins involved in HIV-1 budding—tumor susceptibility gene 101 (Tsg101), a subunit of the endosomal sorting complex required for transport I (ESCRT-I), and Alix, an ESCRT-associated protein—were recruited to the midbody during cytokinesis by interaction with centrosome protein 55 (Cep55), a centrosome and midbody protein essential for abscission. Tsg101, Alix, and possibly other components of ESCRT-I were required for the completion of cytokinesis. Thus, HIV-1 budding and cytokinesis use a similar subset of cellular components to carry out topologically similar membrane fission events.</jats:p>","journal":"Science","year":2007,"id":42431,"datarank":15.321468658282607,"base_score":6.630683385642372,"endowment":6.630683385642372,"self_citation_contribution":0.994602507846356,"citation_network_contribution":14.326866150436251,"self_endowment_contribution":0.994602507846356,"citer_contribution":14.326866150436251,"corpus_percentile":null,"corpus_rank":null,"citation_count":757,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":201621,"name":"Juan Martin-Serrano","orcid":"0000-0002-8183-3914","position":1,"is_corresponding":false},{"id":202415,"name":"Jez G. 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