{"doi":"10.1126/science.1141453","title":"HIV-1 Proviral DNA Excision Using an Evolved Recombinase","abstract":"<jats:p>HIV-1 integrates into the host chromosome and persists as a provirus flanked by long terminal repeats (LTRs). To date, treatment regimens primarily target the virus enzymes or virus-cell fusion, but not the integrated provirus. We report here the substrate-linked protein evolution of a tailored recombinase that recognizes an asymmetric sequence within an HIV-1 LTR. This evolved recombinase efficiently excised integrated HIV proviral DNA from the genome of infected cells. Although a long way from use in the clinic, we speculate that this type of technology might be adapted in future antiretroviral therapies, among other possible uses.</jats:p>","journal":"Science","year":2007,"id":15840,"datarank":7.759882581528779,"base_score":5.356586274672012,"endowment":5.356586274672012,"self_citation_contribution":0.8034879412008019,"citation_network_contribution":6.956394640327977,"self_endowment_contribution":0.8034879412008019,"citer_contribution":6.956394640327977,"corpus_percentile":null,"corpus_rank":null,"citation_count":211,"citer_count":175,"citers_with_citation_signal":153,"citers_with_endowment":153,"datacite_reuse_total":10,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":119271,"name":"Ilona Hauber","orcid":null,"position":1,"is_corresponding":false},{"id":119272,"name":"Joachim Hauber","orcid":null,"position":2,"is_corresponding":false},{"id":119273,"name":"Frank Buchholz","orcid":null,"position":3,"is_corresponding":false},{"id":119270,"name":"Indrani Sarkar","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.356586274672012,"endowment":5.356586274672012,"datacite_reuse_total":10,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17600219","pmcid":null,"openalex_id":"https://openalex.org/W1974496433","authors":[],"funders":[],"total_grants":0,"fwci":4.1248,"citation_percentile":0.94761459,"influential_citations":7,"citation_trend":[{"year":2012,"count":16},{"year":2013,"count":14},{"year":2014,"count":15},{"year":2015,"count":27},{"year":2016,"count":19},{"year":2017,"count":9},{"year":2018,"count":8},{"year":2019,"count":8},{"year":2020,"count":5},{"year":2021,"count":7},{"year":2022,"count":11},{"year":2023,"count":6},{"year":2024,"count":11},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.1141453","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.1141453","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17600219","host_type":"repository"},{"url":"http://edoc.mpg.de/348509","host_type":"repository"},{"url":"http://hdl.handle.net/21.11116/0000-0001-0F3C-D","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","HIV/AIDS drug development and treatment","CRISPR and Genetic Engineering","Biology","Medicine","Amino Acid Sequence","Base Sequence","DNA Shuffling","DNA, Viral","Directed Molecular Evolution","Escherichia coli","Gene Library","Genome, Human","HIV Long Terminal Repeat","HIV-1","HeLa Cells","Humans","Integrases","Molecular Sequence Data","Mutation","Proviruses","Recombination, Genetic","Virus Integration"],"mesh_terms":["Amino Acid Sequence","Base Sequence","DNA, Viral","Escherichia coli","HeLa Cells","Humans","Molecular Sequence Data","Mutation","Proviruses","Recombination, Genetic","HIV-1","Gene Library","Genome, Human","HIV Long Terminal Repeat","Virus Integration","Directed Molecular Evolution","Integrases","DNA Shuffling","Hela Cells"],"keywords":["Provirus","Recombinase","Long terminal repeat","Biology","Virology","Genome","DNA","APOBEC","HIV Long Terminal Repeat","Virus","Genetics","Computational biology","Gene","Recombination"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.24515889.v1","title":"Additional file 1 of Quantification of evolved DNA-editing enzymes at scale with DEQSeq","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.24515889","title":"Additional file 1 of Quantification of evolved DNA-editing enzymes at scale with DEQSeq","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26636394.v1","title":"Additional file 5 of Quantification of evolved DNA-editing enzymes at scale with DEQSeq","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26636394","title":"Additional file 5 of Quantification of evolved DNA-editing enzymes at scale with DEQSeq","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26636388.v1","title":"Additional file 3 of Quantification of 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