{"doi":"10.1126/science.1136281","title":"Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension","abstract":"<jats:p>The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2′-deoxyuridine and become mature neurons in the OB.</jats:p>","journal":"Science","year":2007,"id":47503,"datarank":12.382934905840335,"base_score":6.787844982309579,"endowment":6.787844982309579,"self_citation_contribution":1.018176747346437,"citation_network_contribution":11.364758158493897,"self_endowment_contribution":1.018176747346437,"citer_contribution":11.364758158493897,"corpus_percentile":null,"corpus_rank":null,"citation_count":886,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":219814,"name":"Monica Kam","orcid":null,"position":1,"is_corresponding":false},{"id":219815,"name":"Ulf Nannmark","orcid":null,"position":2,"is_corresponding":false},{"id":219816,"name":"Michelle F. Anderson","orcid":null,"position":3,"is_corresponding":false},{"id":219817,"name":"Mathilda Zetterstrom Axell","orcid":null,"position":4,"is_corresponding":false},{"id":219818,"name":"Carsten Wikkelso","orcid":null,"position":5,"is_corresponding":false},{"id":219819,"name":"Stig Holtås","orcid":null,"position":6,"is_corresponding":false},{"id":219820,"name":"Willeke M. C. van Roon-Mom","orcid":null,"position":7,"is_corresponding":false},{"id":219821,"name":"Thomas Björk-Eriksson","orcid":null,"position":8,"is_corresponding":false},{"id":219822,"name":"Claes Nordborg","orcid":null,"position":9,"is_corresponding":false},{"id":219823,"name":"Jonas Frisén","orcid":null,"position":10,"is_corresponding":false},{"id":219824,"name":"Michael Dragunow","orcid":null,"position":11,"is_corresponding":false},{"id":219825,"name":"Richard L. M. Faull","orcid":null,"position":12,"is_corresponding":false},{"id":219826,"name":"Peter S. Eriksson","orcid":null,"position":13,"is_corresponding":false},{"id":219813,"name":"Maurice A. Curtis","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension","abstract":"<jats:p>The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2′-deoxyuridine and become mature neurons in the OB.</jats:p>","is_dataset_classified":null,"base_score":6.787844982309579,"endowment":6.787844982309579,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17303719","pmcid":null,"openalex_id":"https://openalex.org/W2109120242","authors":[],"funders":[],"total_grants":0,"fwci":29.0904,"citation_percentile":1.0,"influential_citations":31,"citation_trend":[{"year":2012,"count":91},{"year":2013,"count":77},{"year":2014,"count":56},{"year":2015,"count":38},{"year":2016,"count":44},{"year":2017,"count":42},{"year":2018,"count":21},{"year":2019,"count":33},{"year":2020,"count":27},{"year":2021,"count":30},{"year":2022,"count":19},{"year":2023,"count":18},{"year":2024,"count":13},{"year":2025,"count":22},{"year":2026,"count":5}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.1136281","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.1136281","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17303719","host_type":"repository"},{"url":"https://lup.lub.lu.se/record/1140552","host_type":"repository"},{"url":"http://hdl.handle.net/2292/13208","host_type":"repository"}],"fields_of_study":["Neurogenesis and neuroplasticity mechanisms","Neuroinflammation and Neurodegeneration Mechanisms","Nerve injury and regeneration","Biology","Medicine","Apoptosis","Basic Helix-Loop-Helix Proteins","Cell Differentiation","Cell Movement","Cell Nucleus","Cell Shape","Doublecortin Domain Proteins","Ependyma","Eye Proteins","Homeodomain Proteins","Humans","Lateral Ventricles","Magnetic Resonance Imaging","Microscopy, Electron","Microtubule-Associated Proteins","Nerve Tissue Proteins","Neural Cell Adhesion Molecule L1","Neurons","Neuropeptides","Olfactory Bulb","Olfactory Pathways","Oligodendrocyte Transcription Factor 2","PAX6 Transcription Factor","Paired Box Transcription Factors","Prosencephalon","Repressor Proteins","Sialic Acids","Stem Cells","Tubulin"],"mesh_terms":["PAX6 Transcription Factor","Oligodendrocyte Transcription Factor 2","Doublecortin Domain Proteins","Cell Differentiation","Cell Movement","Cell Nucleus","Ependyma","Eye Proteins","Humans","Magnetic Resonance Imaging","Microscopy, Electron","Microtubule-Associated Proteins","Nerve Tissue Proteins","Neurons","Neuropeptides","Olfactory Bulb","Olfactory Pathways","Repressor Proteins","Sialic Acids","Stem Cells","Tubulin","Prosencephalon","Apoptosis","Homeodomain Proteins","Lateral Ventricles","Neural Cell Adhesion Molecule L1","Cell Shape","Paired Box Transcription Factors","Basic Helix-Loop-Helix Transcription Factors","Basic Helix-Loop-Helix Proteins"],"keywords":["Olfactory bulb","Rostral migratory stream","Neuroblast","Subventricular zone","Neuroscience","Biology","Olfactory system","Olfactory ensheathing glia","Human brain","Bulb","Anatomy","Progenitor cell","Central nervous system","Cell biology","Neurogenesis","Stem cell","Botany"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-18T18:43:51.384588Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}