{"doi":"10.1126/science.1086860","title":"Synthesis of Carbenes Through Substitution Reactions at a Carbene Center","abstract":"<jats:p>An (amino)(phosphino) carbene can be transformed into (amino)(phosphonio) carbenes, which undergo nucleophilic intermolecular as well as intramolecular substitution reactions at the carbene center. A variety of carbenes can be synthesized starting from a single carbene precursor. The resulting gamut of electronic and steric effects possible should open the way not only to a detailed study of the mechanism, but also to the subsequent improvement of catalytic reactions that involve carbene-transition metal complexes.</jats:p>","journal":"Science","year":2003,"id":36912,"datarank":3.0731286580096575,"base_score":4.290459441148391,"endowment":4.290459441148391,"self_citation_contribution":0.6435689161722588,"citation_network_contribution":2.429559741837399,"self_endowment_contribution":0.6435689161722588,"citer_contribution":2.429559741837399,"corpus_percentile":null,"corpus_rank":null,"citation_count":72,"citer_count":57,"citers_with_citation_signal":54,"citers_with_endowment":54,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":186030,"name":"Antoine Baceiredo","orcid":null,"position":1,"is_corresponding":false},{"id":181974,"name":"Heinz Gornitzka","orcid":null,"position":2,"is_corresponding":false},{"id":186031,"name":"Guy Bertrand","orcid":null,"position":3,"is_corresponding":false},{"id":186029,"name":"Nathalie Merceron-Saffon","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.290459441148391,"endowment":4.290459441148391,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12947194","pmcid":null,"openalex_id":"https://openalex.org/W1985585029","authors":[],"funders":[],"total_grants":0,"fwci":5.3346,"citation_percentile":0.96238536,"influential_citations":1,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":6},{"year":2014,"count":1},{"year":2015,"count":4},{"year":2016,"count":2},{"year":2017,"count":3},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.1086860","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.1086860","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12947194","host_type":"repository"}],"fields_of_study":["N-Heterocyclic Carbenes in Organic and Inorganic Chemistry","Synthetic Organic Chemistry Methods","Catalytic Cross-Coupling Reactions","Chemistry","Medicine"],"mesh_terms":[],"keywords":["Carbene","Transition metal carbene complex","Chemistry","Intramolecular force","Steric effects","Catalysis","Intermolecular force","Nucleophilic substitution","Nucleophile","Photochemistry","Stereochemistry","Combinatorial chemistry","Medicinal chemistry","Organic chemistry","Molecule"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-10T17:49:57.425798Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}