{"doi":"10.1126/science.1080902","title":"Loss of\n                    <i>IGF2</i>\n                    Imprinting: A Potential Marker of Colorectal Cancer Risk","abstract":"Loss of imprinting (LOI), an epigenetic alteration affecting the insulin-like growth factor II gene (IGF2), is found in normal colonic mucosa of about 30% of colorectal cancer (CRC) patients, but it is found in only 10% of healthy individuals. In a pilot study to investigate the utility of LOI as a marker of CRC risk, we evaluated 172 patients at a colonoscopy clinic. The adjusted odds ratio for LOI in lymphocytes was 5.15 for patients with a positive family history [95% confidence interval (95% CI), 1.70 to 16.96; probability P = 0.002], 3.46 for patients with adenomas (95% CI, 1.14 to 11.37; P = 0.026), and 21.7 for patients with CRC (95% CI, 3.48 to 153.6; P = 0.0005). LOI can be assayed with a DNA-based blood test, and it may be a valuable predictive marker of an individual's risk for CRC.","journal":"Science","year":2003,"id":6587,"datarank":0.9889566801213657,"base_score":6.593044534142437,"endowment":6.593044534142437,"self_citation_contribution":0.9889566801213657,"citation_network_contribution":0.0,"self_endowment_contribution":0.9889566801213657,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":729,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0352,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2003-03-14","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":60692,"name":"Marcia Cruz-Correa","orcid":null,"position":1,"is_corresponding":false},{"id":60693,"name":"Francis M. Giardiello","orcid":null,"position":2,"is_corresponding":false},{"id":60694,"name":"David F. Hutcheon","orcid":null,"position":3,"is_corresponding":false},{"id":60695,"name":"David R. Kafonek","orcid":null,"position":4,"is_corresponding":false},{"id":60696,"name":"Sheri Brandenburg","orcid":null,"position":5,"is_corresponding":false},{"id":60697,"name":"Yiqian Wu","orcid":null,"position":6,"is_corresponding":false},{"id":60698,"name":"Xiaobing He","orcid":null,"position":7,"is_corresponding":false},{"id":60699,"name":"Neil R. Powe","orcid":"0000-0003-2347-3620","position":8,"is_corresponding":false},{"id":29384,"name":"Andrew P. Feinberg","orcid":"0000-0002-8364-1991","position":9,"is_corresponding":false},{"id":60700,"name":"Marcia Cruz‐Correa","orcid":"0000-0001-8147-7457","position":10,"is_corresponding":false},{"id":60701,"name":"Sheri A. Brandenburg","orcid":null,"position":11,"is_corresponding":false},{"id":60691,"name":"Hengmi Cui","orcid":"0000-0001-5139-5370","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}