{"doi":"10.1126/science.1078062","title":"Regulation of Chromatin Remodeling by Inositol Polyphosphates","abstract":"Chromatin remodeling is required for efficient transcription of eukaryotic genes. In a genetic selection for budding yeast mutants that were defective in induction of the phosphate-responsive PHO5 gene, we identified mutations in ARG82/IPK2, which encodes a nuclear inositol polyphosphate kinase. In arg82 mutant strains, remodeling of PHO5 promoter chromatin is impaired, and the adenosine triphosphate-dependent chromatin-remodeling complexes SWI/SNF and INO80 are not efficiently recruited to phosphate-responsive promoters. These results suggest a role for the small molecule inositol polyphosphate in the regulation of chromatin remodeling and transcription.","journal":"Science","year":2003,"id":1934,"datarank":0.8782607883303641,"base_score":5.855071922202427,"endowment":5.855071922202427,"self_citation_contribution":0.8782607883303641,"citation_network_contribution":0.0,"self_endowment_contribution":0.8782607883303641,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":348,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0396,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2003-01-03","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":22076,"name":"Elizabeth S. Haswell","orcid":"0000-0002-4246-065X","position":1,"is_corresponding":false},{"id":22077,"name":"Aimee L. Miller","orcid":null,"position":2,"is_corresponding":false},{"id":22078,"name":"Susan R. Wente","orcid":"0000-0002-6240-548X","position":3,"is_corresponding":false},{"id":22080,"name":"Erin K. O’Shea","orcid":"0000-0002-2649-1018","position":5,"is_corresponding":false},{"id":22075,"name":"David J. Steger","orcid":"0000-0003-1610-7024","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}