{"doi":"10.1126/science.1077905","title":"STAT1-Dependent Innate Immunity to a Norwalk-Like Virus","abstract":"<jats:p>Norwalk-like caliciviruses (Noroviruses) cause over 90% of nonbacterial epidemic gastroenteritis worldwide, but the pathogenesis of norovirus infection is poorly understood because these viruses do not grow in cultured cells and there is no small animal model. Here, we report a previously unknown murine norovirus. Analysis of Murine Norovirus 1 infection revealed that signal transducer and activator of transcription 1–dependent innate immunity, but not T and B cell–dependent adaptive immunity, is essential for norovirus resistance. The identification of host molecules essential for murine norovirus resistance may provide targets for prevention or control of an important human disease.</jats:p>","journal":"Science","year":2003,"id":30891,"datarank":16.611198513419794,"base_score":6.723832440821209,"endowment":6.723832440821209,"self_citation_contribution":1.0085748661231815,"citation_network_contribution":15.602623647296612,"self_endowment_contribution":1.0085748661231815,"citer_contribution":15.602623647296612,"corpus_percentile":null,"corpus_rank":null,"citation_count":831,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":127664,"name":"Christiane E. Wobus","orcid":null,"position":1,"is_corresponding":false},{"id":166820,"name":"Margarita Lay","orcid":null,"position":2,"is_corresponding":false},{"id":166822,"name":"John Davidson","orcid":null,"position":3,"is_corresponding":false},{"id":127666,"name":"Herbert W. Virgin","orcid":null,"position":4,"is_corresponding":false},{"id":134245,"name":"Stephanie M. Karst","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":6.723832440821209,"endowment":6.723832440821209,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12624267","pmcid":null,"openalex_id":"https://openalex.org/W2158026372","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI49286","title":null},{"funder_name":"NCI NIH HHS","grant_id":"T32-CA09547","title":null}],"total_grants":2,"fwci":10.5242,"citation_percentile":0.98947941,"influential_citations":67,"citation_trend":[{"year":2012,"count":52},{"year":2013,"count":53},{"year":2014,"count":62},{"year":2015,"count":42},{"year":2016,"count":45},{"year":2017,"count":38},{"year":2018,"count":49},{"year":2019,"count":44},{"year":2020,"count":31},{"year":2021,"count":45},{"year":2022,"count":18},{"year":2023,"count":23},{"year":2024,"count":28},{"year":2025,"count":27},{"year":2026,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.1077905","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.1077905","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12624267","host_type":"repository"}],"fields_of_study":["Viral gastroenteritis research and epidemiology","Animal Virus Infections Studies","Viral Infections and Immunology Research","Biology","Medicine","Animals","B-Lymphocytes","Brain","Caliciviridae Infections","DNA-Binding Proteins","Genes, RAG-1","Genome, Viral","Homeodomain Proteins","Immunity, Innate","Immunocompromised Host","Intestines","Liver","Membrane Proteins","Mice","Mutation","Norovirus","Phylogeny","RNA, Viral","Receptor, Interferon alpha-beta","Receptors, Interferon","STAT1 Transcription Factor","Spleen","T-Lymphocytes","Trans-Activators","Virulence","Interferon gamma Receptor"],"mesh_terms":["Interferon gamma Receptor","Animals","B-Lymphocytes","Brain","DNA-Binding Proteins","Immunity, Innate","Intestines","Liver","Membrane Proteins","Mutation","Phylogeny","RNA, Viral","Spleen","T-Lymphocytes","Virulence","Trans-Activators","Genes, RAG-1","Genome, Viral","Immunocompromised Host","Caliciviridae Infections","Receptors, Interferon","Homeodomain Proteins","Norovirus","STAT1 Transcription Factor","Mice","Receptor, Interferon alpha-beta"],"keywords":["Norovirus","Murine norovirus","Immunity","Virology","Norwalk virus","Innate immune system","Biology","Caliciviridae","Acquired immune system","STAT1","Virus","Microbiology","Immunology","Immune system"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T05:50:21.368948Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}