{"doi":"10.1126/science.1076963","title":"A Distinct Signaling Pathway Used by the IgG-Containing B Cell Antigen Receptor","abstract":"<jats:p>The immunoglobulin G (IgG)–containing B lymphocyte antigen receptor (IgG-BCR) transmits a signal distinct from that of IgM-BCR or IgD-BCR, although all three use the same signal-transducing component, Igα/Igβ. Here we demonstrate that the inhibitory coreceptor CD22 down-modulates signaling through IgM-BCR and IgD-BCR, but not that through IgG-BCR, because of the IgG cytoplasmic tail, which prevents CD22 phosphorylation. These results suggest that the cytoplasmic tail of IgG specifically enhances IgG-BCR signaling by preventing CD22-mediated signal inhibition. Enhanced signaling through IgG-BCR may be involved in efficient IgG production, which is crucial for immunity to pathogens.</jats:p>","journal":"Science","year":2002,"id":623010,"datarank":0.7755725992557229,"base_score":5.170483995038151,"endowment":5.170483995038151,"self_citation_contribution":0.7755725992557229,"citation_network_contribution":0.0,"self_endowment_contribution":0.7755725992557229,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":175,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":145343,"name":"Takahiro Adachi","orcid":null,"position":1,"is_corresponding":false},{"id":1609983,"name":"Jürgen Wienands","orcid":null,"position":2,"is_corresponding":false},{"id":695462,"name":"Takeshi Tsubata","orcid":"0000-0003-0760-1258","position":3,"is_corresponding":false},{"id":1609982,"name":"Chisato Wakabayashi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Distinct Signaling Pathway Used by the IgG-Containing B Cell Antigen Receptor","abstract":"<jats:p>The immunoglobulin G (IgG)–containing B lymphocyte antigen receptor (IgG-BCR) transmits a signal distinct from that of IgM-BCR or IgD-BCR, although all three use the same signal-transducing component, Igα/Igβ. Here we demonstrate that the inhibitory coreceptor CD22 down-modulates signaling through IgM-BCR and IgD-BCR, but not that through IgG-BCR, because of the IgG cytoplasmic tail, which prevents CD22 phosphorylation. These results suggest that the cytoplasmic tail of IgG specifically enhances IgG-BCR signaling by preventing CD22-mediated signal inhibition. Enhanced signaling through IgG-BCR may be involved in efficient IgG production, which is crucial for immunity to pathogens.</jats:p>","is_dataset_classified":null,"base_score":5.170483995038151,"endowment":5.170483995038151,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12493916","pmcid":null,"openalex_id":"https://openalex.org/W2000993160","authors":[],"funders":[],"total_grants":0,"fwci":3.337,"citation_percentile":0.93111938,"influential_citations":0,"citation_trend":[{"year":2012,"count":9},{"year":2013,"count":10},{"year":2014,"count":10},{"year":2015,"count":8},{"year":2016,"count":6},{"year":2017,"count":4},{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":3},{"year":2022,"count":5},{"year":2023,"count":3},{"year":2024,"count":4},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.1076963","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.1076963","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12493916","host_type":"repository"},{"url":"http://hdl.handle.net/11858/00-001M-0000-002B-95BF-F","host_type":"repository"}],"fields_of_study":["T-cell and B-cell Immunology","Immune Cell Function and Interaction","Glycosylation and Glycoproteins Research","Animals","Antigens, CD","Antigens, Differentiation, B-Lymphocyte","B-Lymphocytes","Calcium","Calcium Signaling","Cell Adhesion Molecules","Cells, Cultured","Immunoglobulin D","Immunoglobulin G","Intracellular Signaling Peptides and Proteins","Lectins","Mice","Mitogen-Activated Protein Kinase 1","Mitogen-Activated Protein Kinase 3","Mitogen-Activated Protein Kinases","Phosphorylation","Protein Tyrosine Phosphatase, Non-Receptor Type 6","Protein Tyrosine Phosphatases","Receptors, Antigen, B-Cell","Sialic Acid Binding Ig-like Lectin 2","Signal Transduction","Transfection","Tumor Cells, Cultured"],"mesh_terms":["Animals","Antigens, Differentiation, B-Lymphocyte","B-Lymphocytes","Calcium","Cells, Cultured","Immunoglobulin D","Immunoglobulin G","Phosphorylation","Receptors, Antigen, B-Cell","Transfection","Tumor Cells, Cultured","Signal Transduction","Antigens, CD","Cell Adhesion Molecules","Protein Tyrosine Phosphatases","Mitogen-Activated Protein Kinase 1","Calcium Signaling","Mitogen-Activated Protein Kinases","Lectins","Intracellular Signaling Peptides and Proteins","Mitogen-Activated Protein Kinase 3","Mice","Sialic Acid Binding Ig-like Lectin 2","Protein Tyrosine Phosphatase, Non-Receptor Type 6"],"keywords":["breakpoint cluster region","Immunoglobulin D","B-cell receptor","CD22","Signal transduction","Immunoglobulin G","Molecular biology","Cell biology","Antigen","Phosphorylation","Biology","B cell","Antibody","Chemistry","Receptor","Immunology","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T21:59:04.822253Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}