{"doi":"10.1126/science.1065543","title":"Distinct Effects of T-bet in T\n                    <sub>H</sub>\n                    1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells","abstract":"<jats:p>\n                    T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (T\n                    <jats:sub>H</jats:sub>\n                    ) lymphocytes in part by activating the hallmark T\n                    <jats:sub>H</jats:sub>\n                    1 cytokine, interferon-γ (IFN-γ). IFN-γ is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-γ production in CD4 and NK cells, but not in CD8 cells. This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-γ, is controlled by distinct transcriptional mechanisms within the T cell lineage.\n                  </jats:p>","journal":"Science","year":2002,"id":632235,"datarank":1.060863285080606,"base_score":7.072421900537371,"endowment":7.072421900537371,"self_citation_contribution":1.060863285080606,"citation_network_contribution":0.0,"self_endowment_contribution":1.060863285080606,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1178,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1337617,"name":"Brandon M. Sullivan","orcid":null,"position":1,"is_corresponding":false},{"id":1638749,"name":"Claudia Stemmann","orcid":null,"position":2,"is_corresponding":false},{"id":273148,"name":"Abhay R. Satoskar","orcid":null,"position":3,"is_corresponding":false},{"id":244456,"name":"Barry P. Sleckman","orcid":"0000-0001-8295-4462","position":4,"is_corresponding":false},{"id":34478,"name":"Laurie H. Glimcher","orcid":"0000-0002-4971-0404","position":5,"is_corresponding":false},{"id":1638748,"name":"Susanne J. Szabo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-08-06T09:16:22.452381Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}