{"doi":"10.1126/science/1141515","title":"Wilms Tumor Suppressor WTX Negatively Regulates WNT/ß-Catenin Signaling","abstract":"Aberrant WNT signal transduction is involved in many diseases. In colorectal cancer and melanoma, mutational disruption of proteins involved in the degradation of beta-catenin, the key effector of the WNT signaling pathway, results in stabilization of beta-catenin and, in turn, activation of transcription. We have used tandem-affinity protein purification and mass spectrometry to define the protein interaction network of the beta-catenin destruction complex. This assay revealed that WTX, a protein encoded by a gene mutated in Wilms tumors, forms a complex with beta-catenin, AXIN1, beta-TrCP2 (beta-transducin repeat-containing protein 2), and APC (adenomatous polyposis coli). Functional analyses in cultured cells, Xenopus, and zebrafish demonstrate that WTX promotes beta-catenin ubiquitination and degradation, which antagonize WNT/beta-catenin signaling. These data provide a possible mechanistic explanation for the tumor suppressor activity of WTX.","journal":"Science","year":2007,"id":9456,"datarank":0.9031535024024291,"base_score":6.021023349349527,"endowment":6.021023349349527,"self_citation_contribution":0.9031535024024291,"citation_network_contribution":0.0,"self_endowment_contribution":0.9031535024024291,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":411,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0488,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2007-05-18","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":79563,"name":"Nathan D. Camp","orcid":"0000-0002-1216-5262","position":1,"is_corresponding":false},{"id":79564,"name":"Jason D. Berndt","orcid":"0000-0002-7388-6792","position":2,"is_corresponding":false},{"id":79565,"name":"XianHua Yi","orcid":null,"position":3,"is_corresponding":false},{"id":79566,"name":"Seth J. Goldenberg","orcid":null,"position":4,"is_corresponding":false},{"id":79567,"name":"Charlotte Hubbert","orcid":null,"position":5,"is_corresponding":false},{"id":79568,"name":"Travis L. Biechele","orcid":null,"position":6,"is_corresponding":false},{"id":44837,"name":"Anne-Claude Gingras","orcid":null,"position":7,"is_corresponding":false},{"id":6649,"name":"Ning Zheng","orcid":"0000-0002-1039-1581","position":8,"is_corresponding":false},{"id":79569,"name":"Michael J. MacCoss","orcid":"0000-0003-1853-0256","position":9,"is_corresponding":false},{"id":79570,"name":"Stephane Angers","orcid":null,"position":10,"is_corresponding":false},{"id":79571,"name":"Randall T. Moon","orcid":"0000-0002-9352-1408","position":11,"is_corresponding":false},{"id":44860,"name":"Anne‐Claude Gingras","orcid":"0000-0002-6090-4437","position":12,"is_corresponding":false},{"id":79572,"name":"Stéphane Angers","orcid":"0000-0001-7241-9044","position":13,"is_corresponding":false},{"id":18212,"name":"Michael B. Major","orcid":"0000-0002-6753-8513","position":0,"is_corresponding":true}],"reference_count":12,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}